Browsing College of Health Sciences by Author "Yalcin, Huseyin C."
Now showing items 1-9 of 9
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Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway
Maram, Hasan; Al-Thani, Hassan; El-Menyar, Ayman; Zeidan, Asad; Al-Thani, Asmaa; Yalcin, Huseyin C.... more authors ... less authors ( Elsevier , 2023 , Article Review)Hemodynamic shear stress is one of the major factors that are involved in the pathogenesis of many cardiovascular diseases including atherosclerosis and abdominal aortic aneurysm (AAA), through its modulatory effect on the ... -
Evaluation of Metal-Organic Framework MIL-89 Nanoparticles Toxicity on Embryonic Zebrafish Development
Dana E., Al-Ansari; Al-Badr, Mashael; Zakaria, Zain Z.; Mohamed, Nura Adam; Nasrallah, Gheyath K.; Yalcin, Huseyin C.; Abou-Saleh, Haissam... more authors ... less authors ( Elsevier , 2022 , Article)Metal-Organic Framework MIL-89 nanoparticles garnered remarkable attention for their widespread use in technological applications. However, the impact of these nanomaterials on human and environmental health is still ... -
Fabrication Strategies for Bioceramic Scaffolds in Bone Tissue Engineering with Generative Design Applications
Cinici, Bilal; Yaba, Sule; Kurt, Mustafa; Yalcin, Huseyin C.; Duta, Liviu; Gunduz, Oguzhan... more authors ... less authors ( MDPI , 2024 , Article Review)The aim of this study is to provide an overview of the current state-of-the-art in the fabrication of bioceramic scaffolds for bone tissue engineering, with an emphasis on the use of three-dimensional (3D) technologies ... -
In vivo testing of novel nitric oxide-releasing nanoparticles for alleviating heart failure using the zebrafish embryo model
Maram, Hasan; Zedan, Hadeel T.; Al-Fakhroo, Dana; Elsayed Ibrahim, Hend; Abiib, Sumaya Ibrahim; El-Sherbiny, Ibrahim M.; Yalcin, Huseyin C.... more authors ... less authors ( Elsevier , 2024 , Article)Heart failure (HF) is a multifactorial, heterogeneous systemic disease that is considered one of the leading causes of death and morbidity worldwide. It is well-known that endothelial dysfunction (ED) plays an important ... -
Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model.
Al-Thani, Hissa F; Shurbaji, Samar; Zakaria, Zain Zaki; Hasan, Maram H; Goracinova, Katerina; Korashy, Hesham M; Yalcin, Huseyin C... more authors ... less authors ( MDPI , 2022 , Article)Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells' proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their ... -
The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
Suleiman, Muna; Al Najjar, Afnan; Zakaria, Zain Z.; Ahmed, Rashid; Yalcin, Huseyin C.; Korashy, Hesham M.; Uddin, Shahab; Riaz, Sadaf; Abdulrahman, Nabeel; Mraiche, Fatima... more authors ... less authors ( Springer , 2023 , Article Review)Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ... -
Trilayer composite scaffold for urethral reconstruction: in vitro evaluation of mechanical, biological, and angiogenic properties
Abbas, Tariq O.; Parangusan, Hemalatha; Yalcin, Huseyin C.; Hassan, Mohamed; Zakrif, Lubna; Zandi, Nooshin; Pennisi, Cristian P.... more authors ... less authors ( IOP Publishing , 2024 , Article)Regeneration of damaged urethral tissue remains a major challenge in the field of lower urinary tract reconstruction. To address this issue, various synthetic and natural biodegradable biomaterials are currently being ... -
Use of Animal Models for Investigating Cardioprotective Roles of SGLT2 Inhibitors
Al Thani, Najlaa A.; Hasan, Maram; Yalcin, Huseyin C. ( Springer , 2023 , Article Review)Sodium-glucose co-transporter 2 (SGLT2) inhibitors represent one type of new-generation type 2 diabetes (T2DM) drug treatment. The mechanism of action of an SGLT2 inhibitor (SGLT2i) in treating T2DM depends on lowering ... -
Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity
zakaria, zain z.; benslimane, fatiha m.; nasrallah, gheyath k.; shurbaji, samar; younes, nadin n.; Mraiche, Fatima; Da’as, Sahar I.; yalcin, huseyin c.... more authors ... less authors ( Hindawi Publishing Corporation , 2018 , Article)Over the last decade, the zebrafish (Danio rerio) has emerged as amodel organismfor cardiovascular research.Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish ...