Biomedical Sciences
Recent Submissions
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Afucosylated IgG Promote Thrombosis in Mouse Injected with SARS-CoV-2 Spike Expressing Megakaryocytes
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Despite the prevalence of fucosylated IgG in plasma, specific IgGs with low core fucosylation sporadically emerge in response to virus infections and blood cell alloantigens. This low fucosylation of IgG is implicated in ... -
Parental knowledge and attitudes toward genetic counseling and childhood genetic testing for congenital anomalies in Qatar
( Wiley , 2025 , Article)This study aims to evaluate parental knowledge and attitudes toward genetic counseling and testing in the context of pediatric plastic surgery in Qatar. It assesses baseline knowledge to identify educational gaps and factors ... -
Advancing targeted therapy for colorectal cancer: harnessing ligand-directed enzyme prodrug therapy for highly specific interventions
( Frontiers Media SA , 2025 , Article)Colorectal cancer (CRC) is a significant global health burden, ranking as the third most frequently diagnosed cancer and a leading cause of cancer-related mortality. Current therapeutic modalities face challenges in advanced ... -
Femoral bone mineral density reference values by sex and ethnicity: Findings from the Qatar Biobank study.
( Elsevier , 2025 , Article)Low bone mineral density (BMD) is a major global health concern due to fracture-related morbidity and mortality. BMD is currently assessed by dual-energy X-ray absorptiometry (DXA) against a US reference population. The ... -
Effectiveness of ChAdOx1 nCoV-19 (Vaxzevria) primary series vaccine against SARS-CoV-2 beta and delta variants: a nationwide study
( Springer Nature , 2025 , Article)Background: This study assessed the real-world effectiveness of the ChAdOx1 nCoV-19 vaccine in adults against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, symptomatic infection, and severe ... -
Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar.
( National Center for Biotechnology Information , 2025 , Article)This study investigated the presence of the healthy vaccinee effect-the imbalance in health status between vaccinated and unvaccinated individuals-in two rigorously conducted COVID-19 vaccine effectiveness studies involving ... -
Second-hand smoke exposure level in the household increases risk of chest pain and wheezing: evidence from Qatar biobank
( Elsevier , 2025 , Article)Background: Despite research on the association between second-hand smoke exposure and chest pain/wheezing, evidence on the levels of exposure in the household and their relation to these outcomes is lacking. Our study ... -
Natural Antioxidants as Regulators of Circular RNA Expression and Function
( Wiley , 2025 , Article)Circular RNAs (circRNAs) are a class of noncoding RNAs characterized by covalently closed loop structures that confer high stability and diverse regulatory functions. Emerging evidence suggests that circRNAs modulate gene ... -
Artificial Intelligence in Biomedical Sciences: A Scoping Review
( Frontiers , 2025 , Article)Background: Artificial intelligence (AI) is increasingly playing important roles in healthcare diagnosis, treatment, monitoring, and prevention of diseases. Despite this widespread implementation of AI in biomedical sciences, ... -
Qatar’s National Expanded Metabolic Newborn Screening Program: Incidence and Outcomes
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Newborn screening is an essential public health strategy that aims to detect a range of conditions, including inborn errors of metabolism, in neonates shortly after birth. The timely identification is crucial ... -
Transcriptomic profiling and bioinformatics-driven statistical prioritization of CRC biomarkers: A step toward precision oncology
( Elsevier , 2025 , Article)BackgroundColorectal adenocarcinoma (COAD) is among the most common causes of cancer-related death globally. Early detection and targeted therapy depend on identifying key molecular biomarkers that drive tumor progression. ... -
Environmental Amoxicillin Exposure Induces Cardiotoxicity in Zebrafish Embryos: A Comprehensive Assessment of Heart Function and Molecular Responses
( MDPI , 2025 , Article)Background/Objectives. Environmental pollution poses a significant threat to human health, primarily through the degradation of natural ecosystems. Emerging organic contaminants (EOCs), such as pharmaceuticals like ... -
Characterization of Flow Structure and Wall Shear Stress in Patient-Specific Abdominal Aortic Aneurysm Phantom Using Particle Image Velocimetry
( American Society of Mechanical Engineers (ASME) , 2025 , Article)Abdominal aortic aneurysm (AAA) is an irreversible dilation of the abdominal aorta that carries a significant risk of rupture if not adequately screened and treated. This condition poses a severe threat, with a mortality ... -
Molecular insights and emerging therapeutic perspectives of the lncRNA GAS5/miR-21 axis in cancer, fibrosis, cardiovascular, and immune disorders
( Elsevier , 2025 , Article)Non-coding RNAs (ncRNAs) have redefined the complexity of gene regulation, with the long non-coding (lncRNA) GAS5/miR-21 axis emerging as a critical determinant of cell fate across diverse pathological contexts. This review ... -
Global burden of chikungunya virus infections and the potential benefit of vaccination campaigns
( Nature Research , 2025 , Article)The first vaccine against chikungunya virus (CHIKV) has now been licensed; however, due to a limited knowledge of the underlying global burden, its potential to reduce disease burden remains unknown. We used data from ... -
Immune histories and natural infection protection during the omicron era
( Springer Nature , 2025 , Article)Background: Past immunological events can either enhance or compromise an individual's future immune protection. This study investigated how different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) natural ... -
JAK-STAT Signaling in Autoimmunity and Cancer
( Dove Medical Press Ltd , 2025 , Article Review)The JAK-STAT pathway is an essential cell survival signaling that regulates gene expressions related to inflammation, immunity and cancer. Cytokine receptors, signal transducer and activator of transcription (STAT) proteins, ... -
Insects in agricultural greenhouses: a metagenomic analysis of microbes in Trialeurodes vaporariorum infesting tomato and cucumber crops
( Frontiers Media SA , 2025 , Article)Introduction: With the predicted 9-10 billion world population increase by 2050 and its accompanying need for sustainable food production, and with the harsh climate conditions challenging agriculture and food security in ... -
Machine learning applications in the analysis of sedentary behavior and associated health risks
( Frontiers Media SA , 2025 , Article Review)Background: The rapid advancement of technology has brought numerous benefits to public health but has also contributed to a rise in sedentary lifestyles, linked to various health issues. As prolonged inactivity becomes a ... -
Development of an RT-LAMP Assay for Detecting tet(M) in Enterococcus Species: Enhancing AMR Surveillance Within the One Health Sectors
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)The increasing prevalence of antimicrobial-resistant (AMR) bacteria in humans, animals, and the environment underscores the necessity for a rapid, sensitive, and specific method to identify resistance genes. Objectives: ...
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