عرض بسيط للتسجيلة

المؤلفAlateyah, Nouralhuda
المؤلفAlsafran, Mohammed
المؤلفUsman, Kamal
المؤلفOuhtit, Allal
تاريخ الإتاحة2023-10-10T07:35:59Z
تاريخ النشر2023-10-07
اسم المنشورNutrients
المعرّفhttp://dx.doi.org/10.3390/nu15194276
الاقتباسAlateyah, N.; Alsafran, M.; Usman, K.; Ouhtit, A. Molecular Evidence of Breast Cancer Cell Proliferation Inhibition by a Combination of Selected Qatari Medicinal Plants Crude Extracts. Nutrients 2023, 15, 4276. https://doi.org/10.3390/nu15194276
معرّف المصادر الموحدhttp://hdl.handle.net/10576/48390
الملخص: Breast cancer (BC) is the most common malignancy, and conventional medicine has failed to establish efficient treatment modalities. Conventional medicine failed due to lack of knowledge of the mechanisms that underpin the onset and metastasis of tumors, as well as resistance to treatment regimen. However, Complementary and Alternative medicine (CAM) modalities are currently drawing the attention of both the public and health professionals. Our study examined the effect of a super-combination (SC) of crude extracts, which were isolated from three selected Qatari medicinal plants, on the proliferation, motility and death of BC cells. Our results revealed that SC attenuated cell growth and caused the cell death of MDA-MB-231 cancer cells when compared to human normal neonatal fibroblast cells. On the other hand, functional assays showed that SC reduced BC cell migration and invasion, respectively. SC-inhibited cell cycle and SC-regulated apoptosis was most likely mediated by p53/p21 pathway and p53-regulated Bax/BCL-2/Caspace-3 pathway. Our ongoing experiments aim to validate these in vitro findings in vivo using a BC-Xenograft mouse model. These findings support our hypothesis that SC inhibited BC cell proliferation and induced apoptosis. These findings lay the foundation for further experiments, aiming to validate SC as an effective chemoprevention and/or chemotherapeutic strategy that can ultimately pave the way towards translational research/clinical trials for the eradication of BC.
راعي المشروعThis research was made possible by support from the Qatar University’s-Japan Research Collaboration Grant (M-QJRC-2020-10) and the Qatar National Research Fund (UREP21-080-1-015 and UREP29-186-3-059).
اللغةen
الناشرMDPI
الموضوعbreast tumors
cell growth and cell survival
cell death
cell motility and invasion
العنوانMolecular Evidence of Breast Cancer Cell Proliferation Inhibition by a Combination of Selected Qatari Medicinal Plants Crude Extracts
النوعArticle
رقم العدد19
رقم المجلد15
ESSN2072-6643
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة