عرض بسيط للتسجيلة

المؤلفTayyem, Reema F.
المؤلفBawadi, Hiba A.
المؤلفShehadah, Ihab N.
المؤلفAbu-Mweis, Suhad S.
المؤلفAgraib, Lana M.
المؤلفBani-Hani, Kamal E.
المؤلفAl-Jaberi, Tareq
المؤلفAl-Nusairr, Majed
المؤلفHeath, Dennis D.
تاريخ الإتاحة2016-10-11T07:13:23Z
تاريخ النشر2015-03-10
اسم المنشورNutrients
المعرّفhttp://dx.doi.org/10.3390/nu7031769
الاقتباسTayyem, R.F.; Bawadi, H.A.; Shehadah, I.N.; Abu-Mweis, S.S.; Agraib, L.M.; Bani-Hani, K.E.; Al-Jaberi, T.; Al-Nusairr, M.; Heath, D.D. Macro- and Micronutrients Consumption and the Risk for Colorectal Cancer among Jordanians. Nutrients 2015, 7, 1769-1786.
الرقم المعياري الدولي للكتاب2072-6643
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4861
الملخصOBJECTIVE: Diet and lifestyle have been reported to be important risk factors for the development of colorectal cancer (CRC). However, the association between total energy and nutrient intake and the risk of developing CRC has not been clearly explained. The aim of our study is to examine the relationship between total energy intake and other nutrients and the development of CRC in the Jordanian population. RESEARCH METHODS AND PROCEDURES: Dietary data was collected from 169 subjects who were previously diagnosed with CRC, and 248 control subjects (matched by age, gender, occupation and marital status). These control subjects were healthy and disease free. Data was collected between January 2010 and December 2012, using interview-based questionnaires. Logistic regression was used to evaluate the association between quartiles of total energy, macro- and micronutrient intakes with the risk of developing CRC in our study population. RESULTS: Total energy intake was associated with a higher risk of developing CRC (OR = 2.60 for the highest versus lowest quartile of intake; 95% CI: 1.21-5.56, p-trend = 0.03). Intakes of protein (OR = 3.62, 95% CI: 1.63-8.05, p-trend = 0.002), carbohydrates (OR = 1.41, 95% CI: 0.67-2.99, p-trend = 0.043), and percentage of energy from fat (OR = 2.10, 95% CI: 0.38-11.70, p-trend = 0.009) significantly increased the risk for the development of CRC. Saturated fat, dietary cholesterol and sodium intake showed a significant association with the risk of developing CRC (OR = 5.23, 95% CI: 2.33-11.76; OR = 2.48, 95% CI: 1.18-5.21; and OR = 3.42, 95% CI: 1.59-7.38, respectively), while vitamin E and caffeine intake were indicative of a protective effect against the development of CRC, OR = 0.002 (95% CI: 0.0003-0.011) and 0.023 (95%CI: 0.008-0.067), respectively. CONCLUSION: Our results suggest an increased risk for the development of CRC in subjects with high dietary intake of energy, protein, saturated fat, cholesterol, and sodium, and diets high in vitamin E and caffeine were suggestive of a protective effect against the risk of developing CRC. IMPACT: This is the first study in Jordan to suggest that it may be possible to reduce CRC risk by adjusting the intake of some macro-and micronutrients.
راعي المشروعHigher Council of Science and Technology
اللغةen
الناشرMultidisciplinary Digital Publishing Institute (MDPI)
الموضوعcolorectal cancer
total energy
micronutrients
macronutrient
العنوانMacro- and micronutrients consumption and the risk for colorectal cancer among Jordanians
النوعArticle
الصفحات1769-1786
رقم العدد3
رقم المجلد7
ESSN2072-6643
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة