Show simple item record

AuthorDel Bo', Cristian
AuthorPerna, Simone
AuthorAllehdan, Sabika
AuthorRafique, Ayesha
AuthorSaad, Sara
AuthorAlGhareeb, Fahad
AuthorRondanelli, Mariangela
AuthorTayyem, Reema F.
AuthorMarino, Mirko
AuthorMartini, Daniela
AuthorRiso, Patrizia
Available date2023-11-05T06:14:30Z
Publication Date2023
Publication NameNutrients
ResourceScopus
ISSN20726643
URIhttp://dx.doi.org/10.3390/nu15102250
URIhttp://hdl.handle.net/10576/49011
AbstractThe effectiveness of the Mediterranean diet (MD) in non-alcoholic fatty liver disease (NAFLD) subjects has been evaluated in several randomized controlled trials (RCTs). This systematic review and meta-analysis aimed to evaluate the overall effects of MD intervention in a cohort of NAFLD patients targeting specific markers such as central obesity, lipid profile, liver enzymes and fibrosis, and intrahepatic fat (IHF). Google Scholar, PubMed, and Scopus were explored to collect relevant studies from the last 10 years. RCTs with NAFLD subjects were included in this systematic review with a mean intervention duration from 6 weeks to 1 year, and different intervention strategies, mainly including energy restriction MD (normal or low glycaemic index), low-fat MD with increased monounsaturated and polyunsaturated fatty acids, and increased exercise expenditure. The outcomes measured in this meta-analysis were gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), total cholesterol (TC), waist circumference (WC), and liver fibrosis. Ten randomized controlled trials, which involved a total of 737 adults with NAFLD, were included. According to the results, the MD seems to decrease the liver stiffness (kPa) by –0.42 (CI95% –0.92, 0.09) (p = 0.10) and significantly reduce the TC by –0.46 mg/dl (CI95% –0.55, −0.38) (p = 0.001), while no significant findings were documented for liver enzymes and WC among patients with NAFLD. In conclusion, the MD might reduce indirect and direct outcomes linked with NAFLD severity, such as TC, liver fibrosis, and WC, although it is important to consider the variations across trials. Further RCTs are necessary to corroborate the findings obtained and provide further evidence on the role of the MD in the modulation of other disorders related to NAFLD.
SponsorThe authors acknowledge the support of the APC central fund of the University of Milano.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
Subjecthuman interventions
lipid profile
liver function
Mediterranean diet
nonalcoholic fatty liver disease
TitleDoes the Mediterranean Diet Have Any Effect on Lipid Profile, Central Obesity and Liver Enzymes in Non-Alcoholic Fatty Liver Disease (NAFLD) Subjects? A Systematic Review and Meta-Analysis of Randomized Control Trials
TypeArticle Review
Issue Number10
Volume Number15
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record