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المؤلفArshad, Muhammad
المؤلفSiddiqa, Maryam
المؤلفRashid, Saddaf
المؤلفHashmi, Imran
المؤلفAwan, Muhammad Ali
المؤلفAli, Muhammad Arif
تاريخ الإتاحة2016-10-19T07:05:27Z
تاريخ النشر2016-06
اسم المنشورSafety and Health at Work
المعرّفhttp://dx.doi.org/10.1016/j.shaw.2015.11.001
الاقتباسMuhammad Arshad, Maryam Siddiqa, Saddaf Rashid, Imran Hashmi, Muhammad Ali Awan, Muhammad Arif Ali, Biomonitoring of Toxic Effects of Pesticides in Occupationally Exposed Individuals, Safety and Health at Work, Volume 7, Issue 2, June 2016, Pages 156-160,
الرقم المعياري الدولي للكتاب20937911
معرّف المصادر الموحدhttp://www.sciencedirect.com/science/article/pii/S2093791115000943
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4903
الملخصBackground Workers in pesticide manufacturing industries are constantly exposed to pesticides. Genetic biomonitoring provides an early identification of potential cancer and genetic diseases in exposed populations. The objectives of this biomonitoring study were to assess DNA damage through comet assay in blood samples collected from industry workers and compare these results with those of classical analytical techniques used for complete blood count analysis. Methods Samples from controls (n = 20) and exposed workers (n = 38) from an industrial area in Multan, Pakistan, were subjected to various tests. Malathion residues in blood samples were measured by gas chromatography. Results The exposed workers who were employed in the pesticide manufacturing industry for a longer period (i.e., 13–25 years) had significantly higher DNA tail length (7.04 μm) than the controls (0.94 μm). Workers in the exposed group also had higher white blood cell and red blood cell counts, and lower levels of mean corpuscular hemoglobin (MCH), MCH concentration, and mean corpuscular volume in comparison with normal levels for these parameters. Malathion was not detected in the control group. However, in the exposed group, 72% of whole blood samples had malathion with a mean value of 0.14 mg/L (range 0.01–0.31 mg/L). Conclusion We found a strong correlation (R2 = 0.91) between DNA damage in terms of tail length and malathion concentration in blood. Intensive efforts and trainings are thus required to build awareness about safety practices and to change industrial workers' attitude to prevent harmful environmental and anthropogenic effects.
راعي المشروعHigher Education Commission of Pakistan (Grant No. PM-IPFP/HRD/HEC/2010/1501). Open Access funded by Occupational Safety and Health Research Institute
اللغةen
الناشرElsevier
الموضوعcomet assay
DNA damage
genotoxicity
hematological tests
malathion
العنوانBiomonitoring of Toxic Effects of Pesticides in Occupationally Exposed Individuals
النوعArticle
الصفحات156-160
رقم العدد2
رقم المجلد7
Open Access user License http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.accessType Open Access


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