عرض بسيط للتسجيلة

المؤلفHasan, Anwarul
المؤلفWaters, Renae
المؤلفRoula, Boustany
المؤلفDana, Rahbani
المؤلفYara, Seif
المؤلفAlexandre, Toubia
المؤلفPaul, Arghya
تاريخ الإتاحة2016-10-24T09:37:53Z
تاريخ النشر2016-03-08
اسم المنشورMacromolecular Bioscience
المعرّفhttp://dx.doi.org/10.1002/mabi.201500396
الاقتباسHasan, A., Waters, R., Roula, B., Dana, R., Yara, S., Alexandre, T. and Paul, A. (2016), Engineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy. Macromol. Biosci.,
الرقم المعياري الدولي للكتاب1616-5187
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4921
الملخصCardiovascular disease is a leading cause of death worldwide. Since adult cardiac cells are limited in their proliferation, cardiac tissue with dead or damaged cardiac cells downstream of the occluded vessel does not regenerate after myocardial infarction. The cardiac tissue is then replaced with nonfunctional fibrotic scar tissue rather than new cardiac cells, which leaves the heart weak. The limited proliferation ability of host cardiac cells has motivated investigators to research the potential cardiac regenerative ability of stem cells. Considerable progress has been made in this endeavor. However, the optimum type of stem cells along with the most suitable matrix-material and cellular microenvironmental cues are yet to be identified or agreed upon. This review presents an overview of various types of biofunctional materials and biomaterial matrices, which in combination with stem cells, have shown promises for cardiac tissue replacement and reinforcement. Engineered biomaterials also have applications in cardiac tissue engineering, in which tissue constructs are developed in vitro by combining stem cells and biomaterial scaffolds for drug screening or eventual implantation. This review highlights the benefits of using biomaterials in conjunction with stem cells to repair damaged myocardium and give a brief description of the properties of these biomaterials that make them such valuable tools to the field.
راعي المشروعAnwarul Hasan acknowledges the startup grant and the University Research Board (URB) grant from American University of Beirut, Lebanon, and the National Council for Scientific Research (CNRS) grant, Lebanon, as well as the Farouk Jabre interdisciplinary research award. Arghya Paul acknowledges the University of Kansas New Faculty General Research Fund for support and assistance with this work. The authors also acknowledge an investigator grant provided by the Institutional Development Award (IDeA) from the National Institute of General Medical Sciences (NIGMS) of the NIH Award Number P20GM103638-04 (to A.P.). R.W. acknowledges the financial support from NIGMS (NIH, T32-GM008359) Biotechnology Predoctoral Research Training Program.
اللغةen
الناشرWiley
الموضوعangiogenesis
hydrogel
myocardial infarction
nanomedicine
stem cells
العنوانEngineered Biomaterials to Enhance Stem Cell-Based Cardiac Tissue Engineering and Therapy
النوعArticle
الصفحات958-977
رقم العدد7
رقم المجلد16
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة