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AuthorEl Hasasna, Hussain
AuthorSaleh, Alaaeldin
AuthorAl Samri, Halima
AuthorAthamneh, Khawlah
AuthorAttoub, Samir
AuthorArafat, Kholoud
AuthorBenhalilou, Nehla
AuthorAlyan, Sofyan
AuthorViallet, Jean
AuthorAl Dhaheri, Yusra
AuthorEid, Ali
AuthorIratni, Rabah
Available date2016-10-31T07:55:58Z
Publication Date2016-02-18
Publication NameScientific Reports
Identifierhttp://dx.doi.org/10.1038/srep21144
CitationEl Hasasna H, Saleh A, Samri HA, et al. Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways. Scientific Reports. 2016;6:21144.
URIhttp://hdl.handle.net/10576/4940
AbstractRecently, we reported that Rhus coriaria exhibits anticancer activities by promoting cell cycle arrest and autophagic cell death of the metastatic triple negative MDA-MB-231 breast cancer cells. Here, we investigated the effect of Rhus coriaria on the migration, invasion, metastasis and tumor growth of TNBC cells. Our current study revealed that non-cytotoxic concentrations of Rhus coriaria significantly inhibited migration and invasion, blocked adhesion to fibronectin and downregulated MMP-9 and prostaglandin E2 (PgE2). Not only did Rhus coriaria decrease their adhesion to HUVECs and to lung microvascular endothelial (HMVEC-L) cells, but it also inhibited the transendothelial migration of MDA-MB-231 cells through TNF-α-activated HUVECs. Furthermore, we found that Rhus coriaria inhibited angiogenesis, reduced VEGF production in both MDA-MB-231 and HUVECs and downregulated the inflammatory cytokines TNF-α, IL-6 and IL-8. The underlying mechanism for Rhus coriaria effects appears to be through inhibiting NFκB, STAT3 and nitric oxide (NO) pathways. Most importantly, by using chick embryo tumor growth assay, we showed that Rhus coriaria suppressed tumor growth and metastasis in vivo. The results described in the present study identify Rhus coriaria as a promising chemopreventive and therapeutic candidate that modulate triple negative breast cancer growth and metastasis.
SponsorUAEU Program for Advanced Research (Grant 31S111-UPAR), the Zayed Center for Health Sciences (ZCHS) research grant (grant 31R021) and the Terry Fox Foundation Grant (2013) to Rabah Iratni.
Languageen
PublisherNature Publishing Group
SubjectBreast cancer
cancer treatment
herbal medicine
Target identification
TitleRhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways
TypeArticle
Volume Number6
ESSN2045-2322
dc.accessType Open Access


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