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AuthorJanket, Sok-Ja
AuthorFraser, Douglas D
AuthorBaird, Alison E
AuthorTamimi, Faleh
AuthorSohaei, Dorsa
AuthorConte, Harry A
AuthorPrassas, Ioannis
AuthorDiamandis, Eleftherios P
Available date2023-12-28T05:14:42Z
Publication Date2023
Publication NameThe Lancet Microbe
ResourceScopus
ISSN26665247
URIhttp://dx.doi.org/10.1016/S2666-5247(23)00111-8
URIhttp://hdl.handle.net/10576/50642
AbstractThe most prevalent symptoms of post-COVID-19 condition are pulmonary dysfunction, fatigue and muscle weakness, anxiety, anosmia, dysgeusia, headaches, difficulty in concentrating, sexual dysfunction, and digestive disturbances. Hence, neurological dysfunction and autonomic impairments predominate in post-COVID-19 condition. Tachykinins including the most studied substance P are neuropeptides expressed throughout the nervous and immune systems, and contribute to many physiopathological processes in the nervous, immune, gastrointestinal, respiratory, urogenital, and dermal systems and participate in inflammation, nociception, and cell proliferation. Substance P is a key molecule in neuroimmune crosstalk; immune cells near the peripheral nerve endings can send signals to the brain with cytokines, which highlights the important role of tachykinins in neuroimmune communication. We reviewed the evidence that relates the symptoms of post-COVID-19 condition to the functions of tachykinins and propose a putative pathogenic mechanism. The antagonism of tachykinins receptors can be a potential treatment target.
Languageen
PublisherElsevier
SubjectTachykinins
COVID-19
pulmonary dysfunction
TitleTachykinins and the potential causal factors for post-COVID-19 condition
TypeArticle Review
Paginatione642-e650
Issue Number8
Volume Number4
dc.accessType Open Access


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