Green synthesis of copper nanoparticles from Nigella sativa seed extract and evaluation of their antibacterial and antiobesity activity

Abstract

In this study, the copper nanoparticles were synthesized using various concentrations (5%, 6 %, 8%, and 10%) of Nigella sativa seed extracts, and their antibacterial and antiobesity effect was evaluated. The optimum particle size (98.23 nm) of nanoparticles was obtained at an extract concentration of 8%. FTIR results confirmed the functional groups responsible for copper ion reduction, The synthesized nanoparticles exhibited high antibacterial activity against Pseudomonas aeruginosa and Escherichia coli having inhibition zone of 25 mm and 24 mm, respectively. Significantly (P < 0.005) percent lipase and amylase inhibition assay of copper nanoparticles confirmed their antiobesity activities.