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AuthorHassan ,Saad S. M.
AuthorElnemma ,Eman M.
AuthorAbbas, Alaa B
Available date2024-03-04T08:58:29Z
Publication Date1997
Publication NameJournal of Pharmaceutical and Biomedical Analysis
ResourceScopus
ISSN0731-7085
URIhttp://dx.doi.org/10.1016/S0731-7085(97)00019-8
URIhttp://hdl.handle.net/10576/52642
AbstractNew thin layer densitometry and high performance liquid chromatography (HPLC) methods are described for quantitative determination of glafenine in dosage forms in the presence of its photo-degradation products and in serum in the presence of its metabolites. Mobile phases consisting of toluene- isopropyl alcohol- dimethylformamide water (18:3:1:0.5) and methanol-water-phosphoric acid (80:120:0.5) are found to be efficient for reasonable separation and adequate resolution of glafenine from associated substances by thin layer chromatography (TLC) and HPLC techniques, respectively. The methods are used for the study of glafenine purity, stability, bioavailability, bioequivaIence and tablet dissolution rate. The results obtained by TLC and HPLC techniques are in good agreement and offer the advantages of reproducibility and accuracy.
Languageen
PublisherElsevier
SubjectBioavailability
Bioequivalence
Glafenine assay
Glafenine metabolites
Glafenine photodegradation products
High performance liquid chromatography
Tablet dissolution rate
Thin layer densitometry
TitleDetermination of glafenine in dosage forms and serum by thin layer densitometry and high performance liquid chromatography
TypeArticle
Pagination215-221
Issue Number2
Volume Number16
dc.accessType Abstract Only


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