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AuthorHassan, Saad S. M.
AuthorEl-Naby, Eman H.
AuthorElnemma, Eman M.
Available date2024-03-04T08:58:29Z
Publication Date1996
Publication NameMikrochimica Acta
ResourceScopus
ISSN0026-3672
URIhttp://dx.doi.org/10.1007/BF01244957
URIhttp://hdl.handle.net/10576/52645
AbstractA simple, accurate and selective method is described for the determination of morphine in illicit powders, based on monitoring the initial rate of fluoride ion liberation from the reaction of morphine with 1-fluoro-2,4-dinitrobenzene at pH 9 and 35 °C, using a solid-state fluoride ion-selective electrode. Under optimized reaction conditions, as little as 15 μg/ml of morphine is determined with an average recovery of 99.5% and a mean relative standard deviation of 1.2%. Determination of morphine in real illicit powders containing 6–18% morphine gives results comparing favorably with those obtained from isocratic reverse-phase high-performance liquid chromatography. No interferences are caused by many structurally related and associated compounds such as codeine, acetylcodeine, ethylmorphine, acetylmorphine and diacetylmorphine (heroin).
Languageen
PublisherSpringer New York
Subject1-fluoro-2
4-dinitrobenzene
Determination of morphine
Fluoride electrode
Illicit powders
Kinetic analysis
Potentiometry
TitleKinetic Determination of Morphine in Illicit Powders, Using a Fluoride Selective Electrode, Based on Reaction with 1-Fluoro-2,4-dinitrobenzene
TypeArticle
Pagination55-62
Issue Number2-Jan
Volume Number124
dc.accessType Abstract Only


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