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المؤلفMedi, Bijan
المؤلفKazi, Monzure-Khoda
المؤلفAmanullah, Mohammad
تاريخ الإتاحة2024-03-19T06:07:44Z
تاريخ النشر2013
اسم المنشورIOP Conference Series: Materials Science and Engineering
المصدرScopus
الرقم المعياري الدولي للكتاب17578981
معرّف المصادر الموحدhttp://dx.doi.org/10.1088/1757-899X/46/1/012021
معرّف المصادر الموحدhttp://hdl.handle.net/10576/53202
الملخصChromatography has been established as the method of choice for the separation and purification of optically pure drugs which has a market size of about 250 billion USD. Single column chromatography (SCC) is commonly used in the development and testing phase of drug development while multi-column Simulated Moving Bed (SMB) chromatography is more suitable for large scale production due to its continuous nature. In this study, optimal performance of SCC and SMB processes for the separation of optical isomers under linear and overloaded separation conditions has been investigated. The performance indicators, namely productivity and desorbent requirement have been compared under geometric similarity for the separation of a mixture of guaifenesin, and Tröger's base enantiomers. SCC process has been analyzed under equilibrium assumption i.e., assuming infinite column efficiency, and zero dispersion, and its optimal performance parameters are compared with the optimal prediction of an SMB process by triangle theory. Simulation results obtained using actual experimental data indicate that SCC may compete with SMB in terms of productivity depending on the molecules to be separated. Besides, insights into the process performances in terms of degree of freedom and relationship between the optimal operating point and solubility limit of the optical isomers have been ascertained. This investigation enables appropriate selection of single or multi-column chromatographic processes based on column packing properties and isotherm parameters.
اللغةen
الموضوعChromatographic process
Development and testing
Large scale productions
Optimal operating point
Performance indicators
Separation and purification
Simulated moving bed chromatography
Simulated moving bed process
Dispersions
Drug products
Isomers
Manufacture
Optimization
Productivity
Separation
Column chromatography
العنوانOptimal performance of single-column chromatography and simulated moving bed processes for the separation of optical isomers
النوعConference
رقم العدد1
رقم المجلد46
dc.accessType Abstract Only


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