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المؤلفAmir, Elhadad
المؤلفMezour, Mohamed A.
المؤلفAbu Nada, Lina
المؤلفShurbaji, Samar
المؤلفMansour, Alaa
المؤلفSmith, Sophia
المؤلفMoussa, Hanan
المؤلفlee, Lisa
المؤلفPérez-Soriano, Eva M.
المؤلفMurshed, Monzur
المؤلفChromik, Richard
المؤلفTamimi, Faleh
تاريخ الإتاحة2024-05-21T10:18:17Z
تاريخ النشر2024-02-27
اسم المنشورMaterials Chemistry and Physics
المعرّفhttp://dx.doi.org/10.1016/j.matchemphys.2024.129114
الرقم المعياري الدولي للكتاب0254-0584
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S0254058424002396
معرّف المصادر الموحدhttp://hdl.handle.net/10576/55239
الملخصTitanium and its alloys are essential metals for orthopedic implant manufacturing due to their exceptional mechanical properties and biocompatibility, used extensively for treating various orthopedic conditions. However, Titanium (Ti) implants have a disadvantage due to lack of bioactivity, potentially affecting osseointegration and osteoconductive capabilities, and may take several months to integrate with bone tissue. In this work, we prepared a layer of 2D magnesium phosphate (MgPi) coating on the surface of titanium surfaces via the spin-coating technique. Various techniques were used to study the phase composition of the coatings, including FTIR, Raman spectroscopy, NMR, and XRD analysis. Morphology and chemical analysis were performed using Atomic force microscopy and SEM/EDX. Nano-scratch test and water contact angle measurements were used to measure adhesion strength and wettability. In addition, in vitro cell assays were used to assess cell adhesion and viability to determine how the MC3T3-E1 osteoblast-like cells reacted to the different treated Ti substrates. AFM results showed that the surface roughness became lower after coatings. MgPi-coated samples showed higher hydrophilicity, protein adsorption, and cell viability than uncoated samples. The nano-scratch test showed that the MgPi coating showed better adherence to chemically and thermally treated samples compared to untreated samples. The deposited MgPi coating has good adhesion to the Ti-substrates. Most significantly, compared to uncoated control (Ti) (p < 0.005) and chemically treated coated samples CT-MgPi (p < 0.005), MC3T3-E1 cell proliferation was significantly increased on thermochemical coated surfaces. These findings point to resorbable two-dimensional MgPi coatings as a potential candidate for promoting Ti implant osseointegration.
راعي المشروعThe authors would like to acknowledge Le Réseau de recherche en santé buccodentaire et osseuse (RSBO) , Canada Research Chairs (CRC) , the Natural Sciences and Engineering Research Council of Canada (NSERC) for their financial support, Qatar University , and the Libyan ministry of education and scientific research .
اللغةen
الموضوعTitanium
Bioactivity
Magnesium phosphate
Coatings
Protein adsorption
العنوان2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces
النوعArticle
رقم المجلد316
Open Access user License http://creativecommons.org/licenses/by/4.0/
ESSN1879-3312
dc.accessType Full Text


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