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المؤلفQurrat-ul-Ain
المؤلفAshiq, Uzma
المؤلفJamal, Rifat Ara
المؤلفSaleem, Muhammad
المؤلفMahroof-Tahir, Mohammad
تاريخ الإتاحة2017-06-05T07:03:20Z
تاريخ النشر2017-05
اسم المنشورArabian Journal of Chemistry
المعرّفhttp://dx.doi.org/10.1016/j.arabjc.2015.02.024
الاقتباسQurrat-ul-Ain, Uzma Ashiq, Rifat Ara Jamal, Muhammad Saleem, Mohammad Mahroof-Tahir, Alpha-glucosidase and carbonic anhydrase inhibition studies of Pd(II)-hydrazide complexes, Arabian Journal of Chemistry, Volume 10, Issue 4, May 2017, Pages 488-499
الرقم المعياري الدولي للكتاب18785352
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5546
الملخصThis study focused on the synthesis and characterization of hydrazide ligands and their respective Pd(II) complexes and used high throughput screening to determine their α-glucosidase and carbonic anhydrase II enzyme inhibition activities. The physical, analytical (elemental analyses for C, H, N and Pd) and spectral (FT-IR, 1H NMR, 13C NMR, EI-mass) techniques utilized during characterization revealed the formation of square planar, neutral and 1:2 Pd(II)-hydrazide complexes with the general formula [PdL2Cl2]. In these Pd(II) complexes, the hydrazide ligands are monodentate; the terminal nitrogen is the donor atom. The uncoordinated hydrazide ligands were inactive against both α-glucosidase and carbonic anhydrase II enzymes; however, the respective Pd(II)-hydrazide complexes were approximately 300 times more potent α-glucosidase inhibitors than the standard compound, 1-deoxynojirimycin (DNJ). Some of the Pd(II) complexes also demonstrated potential carbonic anhydrase (CA) inhibition properties comparable to the standard compound, acetazolamide (ACZ).
راعي المشروعHigher Education Commission of Pakistan for financial support (‘The National Research Grants Program for Universities’, grant No.1862/R&D/10) and MMT acknowledges the support from Fulbright Scholar Award from The J. William Fulbright Foreign Scholarship Board. Open Access funded by King Saud University.
اللغةen
الناشرElsevier
الموضوعCarbonic anhydrase
Enzyme
Hydrazide
Pd(II) complexes
α-Glucosidase
العنوانAlpha-glucosidase and carbonic anhydrase inhibition studies of Pd(II)-hydrazide complexes
النوعArticle
الصفحات488-499
رقم العدد4
رقم المجلد10
dc.accessType Open Access


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