Effect of dietary selenium intake on CVD: A retrospective cohort study based on China Health and Nutrition Survey (CHNS) data

Abstract

Objective: We aimed to examine the association between dietary Se intake and CVD risk in Chinese adults. Design: This prospective cohort study included adults above 20 years old in the China Health and Nutrition Survey (CHNS), and they were followed up from 1997 to 2015 (n 16 030). Dietary data were retrieved from CHNS, and a 3-d, 24-h recall of food intake was used to assess the cumulative average intake of dietary Se, which was divided into quartiles. The Cox proportional hazards model was adopted to analyse the association between dietary Se intake and incident CVD risk. Setting: CHNS (1991, 1993, 1997, 2000, 2004, 2006, 2009, 2011 and 2015) Results: A total of 663 respondents developed CVD after being followed up for a mean of 9·9 years (median 9 years). The incidence of CVD was 4·3, 3·7, 4·6 and 4·0 per 1000 person-years across the quartiles of cumulative Se intake. After adjusting all potential factors, no significant associations were found between cumulative Se intake and CVD risk. No interactions were found between Se intake and income, urbanisation, sex, region, weight, hypertension and CVD risk. Conclusion: We found no association between dietary Se and CVD.