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المؤلفMannem, Radhika
المؤلفYousuf, Mohammed
المؤلفSreerama, Lakshmaiah
تاريخ الإتاحة2024-07-07T09:57:04Z
تاريخ النشر2020-08-06
اسم المنشورFrontiers in Chemistry
المعرّفhttp://dx.doi.org/10.3389/fchem.2020.00684
الاقتباسMannem, R., Yousuf, M., & Sreerama, L. (2020). Nanostructures formed by custom-made peptides based on amyloid peptide sequences and their inhibition by 2-hydroxynaphthoquinone. Frontiers in Chemistry, 8, 684.‏
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85090007776&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/56466
الملخصExtensive research on amyloid fibril formations shows that certain core sequences within Aβ peptide play an important role in their formation. It is impossible to track these events in vivo. Many proteins and peptides with such core sequences form amyloid fibrils and such Aβ sheet mimics have become excellent tools to study amyloid fibril formation and develop therapeutic strategies. A group of peptides based on amyloid peptide sequences obtained from PDB searches, where glycine residues are substituted with alanine and isoleucine, are tested for aggregation by SEM and ThT binding assay. SEM of different peptide sequences showed morphologically different structures such as nanorods, crystalline needles and nanofibrils. The peptides were co-incubated with HNQ (a quinone) to study its effect on the process of aggregation and/or fibrillation. In conclusion, this group of peptides seem to be Aβ sheet mimics and can be very useful in understanding the different morphologies of amyloid fibrils arising from different peptide sequences and the effective strategies to inhibit or anneal them.
اللغةen
الناشرFrontiers Media S.A.
الموضوعamyloid fibrils
Aβ sheet mimics
quinones
SEM
THT
العنوانNanostructures Formed by Custom-Made Peptides Based on Amyloid Peptide Sequences and Their Inhibition by 2-Hydroxynaphthoquinone
النوعArticle
رقم المجلد8
dc.accessType Open Access


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