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Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor.
(
Frontiers Media
, 2022 , Article)
Immune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers. However, patients with HER2+ ...
Haematococcus pluvialis Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells
(
Frontiers Media S.A.
, 2022 , Article)
Breast cancer (BC) is the most common malignant cancer in females worldwide. Drug resistance, toxicity, and the failure of current therapies to completely cure BC has challenged conventional medicine. Consequently, ...
Association between waterpipe smoking and obesity: Population-based study in Qatar
(
European Publishing
, 2022 , Article)
Introduction:
Over the past decade obesity prevalence has been increasing rapidly in the Gulf region (GR) including Qatar, becoming one of the major health issues in the region. Concomitantly, waterpipe (WP) smoking is ...
Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer
(
Elsevier Masson s.r.l.
, 2020 , Article)
Great strides have been made in triple negative breast cancer (TNBC) treatment, which represents 20% of total predicted annual US breast cancer (BC) cases. Despite the development of several therapeutics, TNBC patients ...
Novel polymethoxylated chalcones as potential compounds against kras-mutant colorectal cancers
(
Bentham Science Publishers
, 2020 , Article)
Background/Objective: KRAS-mutant colorectal cancers (CRC) are tumors that are associated with poor prognosis. However, no effective treatments are available to target them. Therefore, we designed and synthesized novel ...
A comprehensive review on the antiviral activities of chalcones
(
Taylor and Francis Ltd.
, 2021 , Article)
Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that ...
Incidence and association of high-risk HPVs and EBV in patients with advanced stages of colorectal cancer from Qatar
(
Taylor and Francis Ltd.
, 2023 , Article)
High-risk Human Papillomaviruses (HPVs) and Epstein-Barr virus (EBV) are present and involved in several types of human carcinomas, including cervical and, head and neck cancers. Nevertheless, their presence and association ...
Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature
(
Elsevier
, 2023 , Article Review)
Gastric cancer, a multifactorial disease, is considered one of the most common malignancies worldwide. In addition to genetic and environmental risk factors, infectious agents, such as Epstein-Barr virus (EBV) and Helicobacter ...
Oncoproteins E6/E7 of the human papillomavirus types 16 & 18 synergize in modulating oncogenes and tumor suppressor proteins in colorectal cancer
(
Taylor and Francis Ltd.
, 2025 , Article)
Objective
Our study presents a novel analysis of the oncogenes and tumor suppressor proteins directly modulated by E6/E7 of high-risk HPV types 16 and 18, in colorectal cancer (CRC).
Methods
HCT 116 (KRAS mutant) & ...
HER-2/Epstein-Barr virus crosstalk in human gastric carcinogenesis: A novel concept of oncogene/oncovirus interaction.
(
Taylor & Francis
, 2018 , Article)
Gastric cancer is the fourth most common cancer and the second leading cause of cancer deaths worldwide. Additionally, it is well-known that metastatic cancer disease is a major cause of morbidity and mortality in cancer ...