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المؤلفEbad Ur Rehman, Mohammad
المؤلفTahir, Ammara
المؤلفHussain, Amna
المؤلفAli, Aizaz
المؤلفBin Gulzar, Abu Huraira
المؤلفKhan, Abdul Qadeer
المؤلفSajjad, Maha
المؤلفShahid, Fatima
المؤلفZahid, Shahroon
المؤلفAslam, Ummara
المؤلفYasin, Talha Bin
المؤلفBilal, Aqsa
المؤلفFatima, Tehreem
المؤلفHameed, Muhammad Sheraz
المؤلفHaider, Tehseen
المؤلفSaeed, Sajeel
المؤلفNashwan, Abdulqadir J.
تاريخ الإتاحة2025-04-13T04:46:18Z
تاريخ النشر2025
اسم المنشورMedical Principles and Practice
المصدرScopus
المعرّفhttp://dx.doi.org/10.1159/000543831
الرقم المعياري الدولي للكتاب10117571
معرّف المصادر الموحدhttp://hdl.handle.net/10576/64155
الملخصBackground: Ustekinumab is an effective drug in the treatment of inflammatory bowel disease (IBD), but inadequate response or loss of response is reported in several patients. Dose escalation by intravenous reinduction or interval shortening may be a suitable option to recapture response. We undertook a systematic review and metaanalysis to assess the efficacy of dose escalation in IBD patients receiving ustekinumab. Methods: A systematic literature search was conducted on PubMed, Embase, Clinicaltrails.gov, and Cochrane from inception to June 1, 2024. We conducted a proportional meta-analysis on MetaXL. Our primary outcomes were clinical response and clinical remission. Results: Twenty-eight articles were included (n = 2,129 patients). Eighteen studies (692 patients out of 1,218) reported clinical response, with pooled prevalence of 55% (95% CI: 46-65%). Out of 1,041 patients, 524 showed clinical remission with pooled prevalence of 51% (95% CI: 42-59%). Conclusion: This systematic review and meta-analysis showcased promising results, in terms of clinical response and remission, in IBD patients receiving dose escalation of ustekinumab.
راعي المشروعOpen access funding was provided by the Qatar National Library. The funder had no role in the design, data collection, data analysis, and reporting of this study.
اللغةen
الناشرS. Karger AG
الموضوعCrohn's disease
Inflammatory bowel disease
Monoclonal antibodies
Ulcerative colitis
العنوانEfficacy of Dose Escalation of Ustekinumab in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
النوعArticle Review
dc.accessType Open Access


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