Central Laboratories Unit
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Central Laboratories Unit Research [110 items ]
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An Eco-Friendly and Sensitive Microwave-Aided Spectrofluorophotometric Characterization of Mirabegron-Loaded Nanocarriers by Amalgamation of Design of Experiments and White Analytical Chemistry
( John Wiley and Sons , 2024 , Article)Mirabegron, a drug for treatment of overactive bladder, has low water solubility and bioavailability. Researchers used quality by design to develop and characterize second-generation lipid nanocarriers for mirabegron, ... -
Microwave-aided sensitive and eco-friendly HPTLC method for estimation of mirabegron using NBD-Cl as bio-sensing fluorescent probe by Integration of principal component Analysis, response surface modelling and white analytical chemistry approach
( Elsevier B.V. , 2024 , Article)A large number of analytical methods have been used in in-vivo pharmacokinetic investigations and assays of mirabegron, which is used to treat overactive bladder. Because mirabegron does not give fluorescence, there is no ... -
Microwave-derivatized enhanced-spectrofluorophotometric characterization of nateglinide-loaded solid dispersion adsorbate and greenness profile assessment of method
( Springer Nature , 2024 , Article)Nateglinide is an oral meglitinide that treats diabetes. Nateglinide was determined in several commercial formulations using chromatographic and spectrophotometric methods in published research. Quality-by-design approach ... -
A Convenient One-Pot Synthesis of Novel Benzimidazole–Thiazinone Derivatives and Their Antimicrobial Activity
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background: The increasing prevalence of antimicrobial resistant highlights the urgent need for the new therapeutic agents. This study aimed to design and synthesize fused tricyclic benzimidazole–thiazinone derivatives ... -
Surface-engineered Niosomes of Esculin Hydrate for the management of depression via intranasal route: Optimization, In vitro, Ex vivo and pharmacokinetic assessment
( Elsevier B.V. , 2024 , Article)Present research explored the potential of surface-engineered niosomes of Esculin hydrate (ESCH), coated with chitosan, as a novel approach for managing depression through intranasal administration. Formulation optimization ... -
Red, green, and blue model assessment and AQbD approach to HPTLC method for concomitant analysis of metformin, pioglitazone, and teneligliptin
( Springer Nature , 2024 , Article)Background The CDSCO of India has authorized a combination of metformin hydrochloride, teneligliptin hydrochloride, and pioglitazone hydrochloride for the treatment of insulin-independent diabetes. For the purpose of ... -
Whiteness, redness, blueness and greenness profile assessment and design of experiments approach to microwave-aided sensitive and green spectrofluorophotometric determination of baclofen
( John Wiley & Sons Ltd. , 2024 , Article)As a gamma amino butyric acid-ergic agonist, Baclofen is often prescribed to adults and children for the treatment of severe spasticity that originates in the brain or spinal cord. Even after reviewing the literature ... -
Bronchodilator Monoterpenes from the Fruits of Trachyspermum ammi L.
( ACG Publications , 2024 , Article)Trachyspermum ammi is widely used among the people in the Arabian Peninsula to treat general respiratory problems including bronchoconstriction. In this study, the fruit extracts and its fractions and purely isolated ... -
Lipid-based nanoparticles: innovations in ocular drug delivery
( Frontiers Media , 2024 , Article Review)Ocular drug delivery presents significant challenges due to intricate anatomy and the various barriers (corneal, tear, conjunctival, blood-aqueous, blood-retinal, and degradative enzymes) within the eye. Lipid-based ... -
Author Correction: Surfactant/organic solvent free single-step engineering of hybrid graphene-Pt/TiO2 nanostructure: Efficient photocatalytic system for the treatment of wastewater coming from textile industries
( Springer Nature , 2019 , Article)A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. -
Carica Papaya leaf-infused metal oxide nanocomposite: a green approach towards water treatment and antibacterial applications
( Springer , 2024 , Article)This study successfully synthesized ZnO–CuO nanocomposite using the hydrothermal method with Carica papaya leaf extract. The incorporation of the leaf extract significantly enhanced the nanocomposite properties, a novel ... -
Role of the intercalated ions on the high capacitance behavior of Ti 3 C 2 Tx MXene nanohybrids
( Taylor and Francis Ltd. , 2023 , Article)Ti3C2Tx (MXene) is prone to surface oxidation because of the presence of oxygen surface terminals in its surfaces. In this work, the effect of oxygen surface terminals has been reduced by replacing it with other surface ... -
Non-covalent functionalization of surfactant-assisted graphene oxide with silver nanocomposites for highly efficient photocatalysis and anti-biofilm applications
( Elsevier , 2024 , Article)This study presents a comprehensive investigation on the synthesis and characterization of surfactant-assisted graphene oxide non-covalent functionalized silver nanocomposites (rGS-AgNPs) for achieving remarkable photocatalytic ... -
Ultratrace determination of strontium-90 in environmental soil samples from Qatar by collision/reaction cell-inductively coupled plasma mass spectrometry (CRC-ICP-MS/MS)
( The American Society of Mechanical Engineers (ASME) , 2014 , Conference)Because of the very low level of 90Sr in the environmental soil samples and its determination by beta counting may take several weeks, we developed a procedure for ultratrace determination of 90Sr using collision reaction ... -
In-vivo pharmacokinetic study of ibrutinib-loaded nanostructured lipid carriers in rat plasma by sensitive spectrofluorimetric method using harmonized approach of quality by design and white analytical chemistry
( Elsevier , 2024 , Article)Ibrutinib, an antineoplastic agent tackling chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom’s Macroglobulinemia, falls under the category of BCS class II drugs, characterized by a puzzling combination ... -
Targeting protein receptors and enzymes for precision management of urolithiasis: A comprehensive review
( Elsevier , 2024 , Article)Urolithiasis, characterized by the formation of solid crystalline structures within the urinary tract, presents a significant global health burden with high recurrence rates and limited treatment efficacy. Recent research ... -
Development of novel nanoemulsion of pioglitazone used in the treatment of diabetes and its gel form for the treatment of skin diseases
( Elsevier , 2024 , Article)Pioglitazone (PGL), an antidiabetic drug within the thiazolidinedione class, is utilized in managing type-2-diabetes-mellitus. Additionally, it has been observed to exhibit therapeutic effects on various inflammatory ... -
A novel mucoadhesive paliperidone-nanoemulsion developed using the ultrasonication method in the treatment of schizophrenia
( Royal Society of Chemistry , 2024 , Article)Aim: To develop paliperidone mucoadhesive-nanoemulsion (PLP-NE) to enhance brain bioavailability. To evaluate comparative effects of PLP-NE and CS-PLP-NE in the treatment of schizophrenia, followed by a toxicity study of ... -
In-Vitro Dissolution Study of Solid Dispersion Adsorbate of Nateglinide by Eco-Friendly Liquid Chromatography-Tandem Mass Spectrometric Method through Harmonized Approach of White Analytical Chemistry and Analytical Quality by Design
( Springer Nature , 2024 , Article)Purpose: Nateglinide, a member of the meglitinide class, is used as an oral antihyperglycemic agent to treat non-insulin-dependent diabetes mellitus. It falls under the BCS class II category and has a low solubility ... -
Significance of Triazole in Medicinal Chemistry: Advancement in Drug Design, Reward and Biological Activity.
( Wiley , 2024 , Article Review)One of the triazole tautomers, 1,2,4-triazole derivatives, has a wide range of biological activities that suggest its potential therapeutic utility in medicinal chemistry. These actions include anti-inflammatory, anti-cancer, ...
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