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المؤلفHussein, Yasser H. A.
المؤلفYoussry, Mohamed
تاريخ الإتاحة2018-04-29T11:12:24Z
تاريخ النشر2018-04-27
اسم المنشورMaterials
المعرّفhttp://dx.doi.org/10.3390/ma11050688
الاقتباسHussein, Y.H.A.; Youssry, M. Polymeric Micelles of Biodegradable Diblock Copolymers: Enhanced Encapsulation of Hydrophobic Drugs. Materials 2018, 11, 688.
الرقم المعياري الدولي للكتاب1996-1944
المعرّفArticle number: 688
معرّف المصادر الموحدhttp://hdl.handle.net/10576/6633
الملخصPolymeric micelles are potentially efficient in encapsulating and performing the controlled release of various hydrophobic drug molecules. Understanding the fundamental physicochemical properties behind drug–polymer systems in terms of interaction strength and compatibility, drug partition coefficient (preferential solubilization), micelle size, morphology, etc., encourages the formulation of polymeric nanocarriers with enhanced drug encapsulating capacity, prolonged circulation time, and stability in the human body. In this review, we systematically address some open issues which are considered to be obstacles inhibiting the commercial availability of polymer-based therapeutics, such as the enhancement of encapsulation capacity by finding better drug–polymer compatibility, the drug-release kinetics and mechanisms under chemical and mechanical conditions simulating to physiological conditions, and the role of preparation methods and solvents on the overall performance of micelles
اللغةen
الناشرMDPI
الموضوعdiblock copolymers
polymeric micelles
drug encapsulation
physicochemical properties
biodegradable
biocompatible copolymers
العنوانPolymeric Micelles of Biodegradable Diblock Copolymers: Enhanced Encapsulation of Hydrophobic Drugs
النوعArticle Review
الصفحات1-26
رقم العدد5
رقم المجلد11
ESSN1996-1944
dc.accessType Open Access


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