Browsing Laboratory Animal Research Center by Author "Crovella, Sergio"
Now showing items 1-7 of 7
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Abrogation of ORF8-IRF3 binding interface with Carbon nanotube derivatives to rescue the host immune system against SARS-CoV-2 by using molecular screening and simulation approaches.
Suleman, Muhammad; Murshed, Abduh; Imran, Kashif; Khan, Abbas; Ali, Zafar; Albekairi, Norah A; Wei, Dong-Qing; Yassine, Hadi M; Crovella, Sergio... more authors ... less authors ( BMC , 2024 , Article)The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to over six million deaths worldwide. In human immune system, the type 1 interferon (IFN) pathway plays a crucial role in fighting viral infections. However, ... -
Analysis of E2F1 single-nucleotide polymorphisms reveals deleterious non-synonymous substitutions that disrupt E2F1-RB protein interaction in cancer
Muhammad, Suleman; Khattak, Aishma; Akbar, Fazal; Rizwan, Muhammad; Tayyab, Muhammad; Yousaf, Muhammad; Khan, Abbas; Albekairi, Norah A.; Agouni, Abdelali; Crovella, Sergio... more authors ... less authors ( Elsevier , 2024 , Article)Cancer is a medical condition that is caused by the abnormal growth and division of cells, leading to the formation of tumors. The E2F1 and RB pathways are critical in regulating cell cycle, and their dysregulation can ... -
Clinical and molecular characterization of hidradenitis suppurativa: a practical framework for novel therapeutic targets.
Moltrasio, Chiara; Tricarico, Paola Maura; Moura, Ronald; Brandao, Lucas André Cavalcanti; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( Karger Publishers , 2023 , Report)Background: The pathophysiological picture underlying hidradenitis suppurativa (HS) and its syndromic forms is still patchy, thus presenting a great challenge for dermatologists and researchers since just by better ... -
Fc Epsilon RI–Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients
Isaifan, Dina; Crovella, Sergio; Soubra, Lama; Al-Nesf, Maryam; Steinhoff, Martin ( MDPI , 2023 , Article Review)Atopic dermatitis (AD) is the most common chronic relapsing neuroinflammatory skin disease that is characterized by a complex and multifactorial pathophysiology. It reflects a profound interplay between genetic and ... -
In silico-designed antimicrobial peptide targeting MRSA and E. coli with antibacterial and antibiofilm actions
Madni, Hafsa; Mohamed, Hana A.; Abdelrahman, Hana Adel Mohamed; dos Santos-Silva, Carlos André; Benko-Iseppon, Ana Maria; Khatir, Zenaba; Eltai, Nahla O.; Mohamed, Nura A.; Crovella, Sergio... more authors ... less authors ( Springer Nature , 2024 , Article)Antibiotic resistance is a paramount global health issue, with numerous bacterial strains continually fortifying their resistance against diverse antibiotics. This surge in resistance levels primarily stems from the overuse ... -
A loss-of-function NCSTN mutation associated with familial Dowling Degos disease and hidradenitis suppurativa
de Oliveira, Ana Sofia Lima Estevao; de Siqueira, Roberta Cardoso; Nait-Meddour, Cécile; Tricarico, Paola Maura; Moura, Ronald; Agrelli, Almerinda; d'Adamo, Adamo Pio; Jamain, Stéphane; Crovella, Sergio; de Fátima Medeiros Brito, Maria; Boniotto, Michele; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Wiley , 2023 , Article)Dowling Degos disease (DDD) is a rare autosomal dominant genodermatosis characterized by acquired, slowly progressive reticulated pigmented lesions primarily involving flexural skin areas. Mutations in KRT5, POGLUT-1 and ... -
The mitochondrial-related effect of the 905 nm photobiomodulation therapy on 50B11 sensory neurons
Zupin, Luisa; Crovella, Sergio; Milena, Cadenaro; Barbi, Egidio; Celsi, Fulvio ( Wiley , 2023 , Article)Photobiomodulation therapy (PBMT) is known as a complementary tool to alleviate pain sensation in patients, nevertheless, there is still a gap of knowledge on its mechanism of action, thus limiting its clinical employment. ...