Laboratory Animal Research Center: المرسلات الحديثة
السجلات المعروضة 21 -- 40 من 163
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Deciphering Mutational Impacts on c-Src-HK2 Interaction in Colorectal Cancer Progression, and Identification of Potential Phytocompounds Inhibitors: A Molecular Simulation and Free Energy Calculation Approach
( Bentham Science Publishers , 2024 , Article)Background: Colorectal cancer (CRC) stands as the third most widespread cancer worldwide in both men and women, witnessing a concerning rise, especially in younger demographics. Abnormal activation of the Non-Receptor ... -
Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis
( Bentham Science Publishers , 2025 , Article Review)Colorectal cancer (CRC) has become a significant threat in recent decades, and its incidence is predicted to continue rising. Despite notable advancements in therapeutic strategies, managing CRC poses complex challenges, ... -
Polygenic Score: A Tool for Evaluating the Genetic Background of Sporadic Hidradenitis Suppurativa
( Elsevier , 2025 , Article)Sporadic hidradenitis suppurativa (spHS) is a multifactorial disease in which genetic predisposition is intertwined with environmental factors. Owing to the still-to-date limited knowledge of spHS genetics, we calculated ... -
Keratin Variants in Pyoderma Gangrenosum: Pathogenetic Insights from a Whole-Exome Sequencing–Based Bioinformatic Analysis
( Elsevier , 2025 , Article)Pyoderma gangrenosum (PG) is an inflammatory skin disorder that belongs to the group of neutrophilic dermatoses. Clinically, it is typified by cutaneous ulcers with distinctive erythematoviolaceous borders and may occur ... -
The effect of near-infrared Photobiomodulation therapy on the ion content of 50B11 sensory neurons measured through XRF analysis
( Elsevier , 2024 , Article)Photobiomodulation therapy (PBMT) is a form of treatment commonly used for routine clinical applications, such as wound healing of the skin and reduction of inflammation. Additionally, PBMT has been explored for its potential ... -
Organ-specific safety profile of bioinspired short antimicrobial peptides in zebrafish embryos
( Frontiers , 2025 , Article)Objective: Antimicrobial peptides (AMPs) are key components of the innate immune system, exhibiting broad-spectrum antibacterial and immunomodulatory activities. Building on these properties, we designed bio-inspired short ... -
PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells
( Springer , 2025 , Article)Cancer stem cells (CSCs) are a small subpopulation bearing self-renewal ability, mediating tumor initiation and propagation. Several molecular pathways, including the PI3K/AKT/mTOR pathway, are known to be aberrantly ... -
Molecular Screening and Free Energy Calculations-Based Exploration of Medicinal Phytocompounds Chemical Space to Abrogate G9R-E4R Complex from Monkeypox: A Current Global Health Threat
( Wiley-VCH , 2025 , Article)The current monkeypox virus outbreak is probably linked with the novel substitutions in the G9R protein of the replication complex. The G9R-E4R interface act as a potential druggable site for the inhibition of monkeypox ... -
JAK-STAT Signaling in Autoimmunity and Cancer
( Dove Medical Press Ltd , 2025 , Article Review)The JAK-STAT pathway is an essential cell survival signaling that regulates gene expressions related to inflammation, immunity and cancer. Cytokine receptors, signal transducer and activator of transcription (STAT) proteins, ... -
Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells
( Elsevier , 2025 , Article)Curcumin, a plant derived natural product isolated from Curcuma longa. The aim of this study is to investigate the anti-proliferative effects and the underlying mechanisms of curcumin in Cutaneous T cell lymphoma (CTCL), ... -
Antiproliferative activity of sesquiterpene lactones from Dittrichia viscosa (L.) Greuter: In vitro and in silico studies
( Society for Medicinal Plant and Natural Product Research (GA) - the Italian Society of Phytochemistry (SIF) , 2025 , Poster)Plant-derived metabolites have provided promising leads in the search for safer anticancer chemo-therapies. Among these, sesquiterpene lactones, predominantly present in the genus of the Aster-aceae family, exhibit great ... -
Phytocompounds as potential inhibitors of p300-HIF1α interaction: A structure-based screening and molecular dynamics simulation analysis
( Society for Medicinal Plant and Natural Product Research (GA) - the Italian Society of Phytochemistry (SIF) , 2025 , Poster)Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1) [1]. For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ... -
In vitro and in silico analysis of anticancer activity of terpenoids of Dittrichia viscosa (L.) Greuter essential oil
( Society for Medicinal Plant and Natural Product Research (GA) - the Italian Society of Phytochemistry (SIF) , 2025 , Poster)There is a continuous global search for new anticancer agents from natural sources. In this study, the essential oils of Dittrichia viscosa (L.) Greuter leaves (DVEO) were extracted by hydrodistillation and chemically ... -
Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1? Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ... -
Association between maternal exposure to polycyclic aromatic hydrocarbons and birth anthropometric outcomes: A systematic review and meta-analysis
( Elsevier , 2024 , Article Review)BackgroundPrevious research has proposed that exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy could potentially lead to a higher risk of adverse birth anthropometric outcomes. However, the current ... -
The apoptotic and anti-proliferative effects of Neosetophomone B in T-cell acute lymphoblastic leukaemia via PI3K/AKT/mTOR pathway inhibition
( John Wiley and Sons Inc , 2025 , Article)The phosphatidylinositol 3-kinase/Protein Kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway is pivotal in various cancers, including T-cell acute lymphoblastic leukaemia (T-ALL), a particularly ... -
Signaling networks guiding erythropoiesis
( Lippincott Williams and Wilkins , 2024 , Article Review)Purpose of reviewCytokine-mediated signaling pathways, including JAK/STAT, PI3K/AKT, and Ras/MAPK pathways, play an important role in the process of erythropoiesis. These pathways are involved in the survival, proliferation, ... -
Deregulated transcription factors in the emerging cancer hallmarks
( Elsevier , 2024 , Article)Cancer progression is a multifaceted process that entails several stages and demands the persistent expression or activation of transcription factors (TFs) to facilitate growth and survival. TFs are a cluster of proteins ... -
Exploiting transcription factors to target EMT and cancer stem cells for tumor modulation and therapy
( Elsevier , 2024 , Article)Transcription factors (TFs) are essential in controlling gene regulatory networks that determine cellular fate during embryogenesis and tumor development. TFs are the major players in promoting cancer stemness by regulating ... -
The cross-talk between miRNAs and JAK/STAT pathway in cutaneous T cell lymphoma: Emphasis on therapeutic opportunities
( Elsevier , 2024 , Article Review)Mycosis Fungoides (MF) and Sézary Syndrome (SS) belong to a wide spectrum of T cell lymphoproliferative disorders collectively termed cutaneous T cell lymphomas (CTCL). CTCLs represent an archetype of heterogeneous and ...
