تصفح حسب المؤلف "Hindy, George"
السجلات المعروضة 1 -- 16 من 16
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A meta-review of meta-analyses and an updated meta-analysis on the efficacy of chloroquine and hydroxychloroquine in treating COVID19 infection
( Qatar University Press , 2020 , Poster)Objective: To synthesize the findings presented in systematic reviews and meta-analyses as well as to update the evidence using a meta-analysis in evaluating the efficacy and safety of CQ and HCQ with or without Azithromycin ... -
Association of Habitual Alcohol Intake with Risk of Cardiovascular Disease
( American Medical Association , 2022 , Article)Importance: Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie, mendelian randomization studies) have suggested a possible ... -
Blood pressure and bladder cancer risk in men by use of survival analysis and in interaction with NAT2 genotype, and by Mendelian randomization analysis
( Public Library of Science , 2020 , Article)The association between blood pressure (BP) and bladder cancer (BC) risk remains unclear with confounding by smoking being of particular concern. We investigated the association between BP and BC risk among men using ... -
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
( Nature Research , 2022 , Article)The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) ... -
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
( Nature Research , 2020 , Article)Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose ... -
Efficacy of chloroquine and hydroxychloroquine in treating COVID-19 infection: A meta-review of systematic reviews and an updated meta-analysis
( Elsevier , 2021 , Article)To synthesize findings from systematic reviews and meta-analyses on the efficacy and safety of chloroquine (CQ) and hydroxychloroquine (HCQ) with or without Azithromycin for treating COVID-19, and to update the evidence ... -
Genome-wide polygenic score, clinical risk factors, and long-term trajectories of coronary artery disease
( American Heart Association , 2020 , Article)OBJECTIVE: To determine the relationship of a genome-wide polygenic score for coronary artery disease (GPSCAD) with lifetime trajectories of CAD risk, directly compare its predictive capacity to traditional risk factors, ... -
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
( BioMed Central , 2022 , Article)Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding ... -
Increased soluble urokinase plasminogen activator levels modulate monocyte function to promote atherosclerosis
( American Society for Clinical Investigation , 2022 , Article)People with kidney disease are disproportionately affected by atherosclerosis for unclear reasons. Soluble urokinase plasminogen activator receptor (suPAR) is an immune-derived mediator of kidney disease, levels of which ... -
Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort
( Nature Research , 2021 , Article)Novel methods to characterize the plasma proteome has made it possible to examine a wide range of proteins in large longitudinal cohort studies, but the complexity of the human proteome makes it difficult to identify robust ... -
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
( Elsevier , 2022 , Article)A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ... -
The odds ratio is “portable” but not the relative risk: Time to do away with the log link in binomial regression
( Elsevier , 2021 , Article)Objectives: In a recent paper we suggest that the relative risk (RR) be replaced with the odds ratio (OR) as the effect measure of choice in clinical epidemiology. In response, Chu, and colleagues raise several points that ... -
The power of genetic diversity in genome-wide association studies of lipids
( Nature Research , 2021 , Article)Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in ... -
The prevalence of adaptive immunity to COVID-19 and reinfection after recovery - a comprehensive systematic review and meta-analysis.
( Taylor & Francis , 2022 , Article)This study aims to estimate the prevalence and longevity of detectable SARS-CoV-2 antibodies and T and B memory cells after recovery. In addition, the prevalence of COVID-19 reinfection and the preventive efficacy of ... -
The prevalence of adaptive immunity to COVID-19 and reinfection after recovery - a comprehensive systematic review and meta-analysis of 12 011 447 individuals
( Qatar University Press , 2021 , Poster)Research purpose: The research aims to estimate the prevalence of detectable SARS-CoV-2 antibodies, T and B memory cells after recovery, to determine the prevalence of SARS-CoV-2 reinfection, and to investigate the protective ... -
Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease.
( American Heart Association , 2020 , Article)N/A
