Browsing by Author "Afifi, N."
Now showing items 1-9 of 9
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A Comparison Study in the Management of Ectopic Pregnancy between State of Qatar and Kingdom of Bahrain
Afifi, N.; El Taher, F.; Al Tamimi, H.; El Sayed, N. ( Hamad bin Khalifa University Press (HBKU Press) , 2007 , Article)Ectopic pregnancy is of increasing concern to gynecologists since it is a major cause of maternal mortality and morbidity in reproductive age women. It occurs when the conceptus implants in an abnormal position other than ... -
Current progress in chimeric antigen receptor T cell therapy for glioblastoma multiforme
Marei H.E.; Althani A.; Afifi N.; Hasan, Anwarul; Caceci T.; Pozzoli G.; Cenciarelli C.... more authors ... less authors ( John Wiley and Sons Inc , 2021 , Article)Glioblastoma multiforme (GBM) is one of the deadliest brain tumors with an unfavorable prognosis and overall survival of approximately 20 months following diagnosis. The current treatment for GBM includes surgical resections ... -
Exome sequencing of glioblastoma-derived cancer stem cells reveals rare clinically relevant frameshift deletion in MLLT1 gene
Marei H.E.; Althani A.; Afifi N.; Hasan, Anwarul; Caceci T.; Felsani A.; Tringali G.; Cifola I.; Pozzoli G.; Cenciarelli C.... more authors ... less authors ( BioMed Central Ltd , 2022 , Article)Background: Glioblastoma multiforme (GBM) is a heterogeneous CNS neoplasm which causes significant morbidity and mortality. One reason for the poor prognostic outcome of GBM is attributed to the presence of cancer stem ... -
Generation of gene edited hiPSC from familial Alzheimer's disease patient carrying N141I missense mutation in presenilin 2
Marei H.E.; Althani A.; Afifi N.; Hasan, Anwarul; Caceci T.; Pozzoli G.; Cenciarelli C.... more authors ... less authors ( Elsevier B.V. , 2021 , Article)Alzheimer's disease (AD) is the major cause of dementia worldwide. Early-onset familial AD accounts for about 0.5% of all AD and is caused by single major gene mutations and autosomal dominant inheritance. An N141I missense ... -
Nanotubes Impregnated Human Olfactory Bulb Neural Stem Cells Promote Neuronal Differentiation in Trimethyltin-induced Neurodegeneration Rat Model
Marei, H.; Elnegiry, A.; Zaghloul, A.; Althani, A.; Afifi, N.; Abd-Elmaksoud, A.; Farag, A.; Lashen, S.; Rezk, S.; Shouman, Z.; Cenciarelli, C.; Hasan, A.... more authors ... less authors ( Wiley , 2017 , Article)Neural stem cells (NSCs) are multipotent self-renewing cells that could be used in cellular-based therapy for a wide variety of neurodegenerative diseases including Alzheimer's diseases (AD), Parkinson's disease (PD), ... -
p53 signaling in cancer progression and therapy
Marei H.E.; Althani A.; Afifi N.; Hasan, Anwarul; Caceci T.; Pozzoli G.; Morrione A.; Giordano A.; Cenciarelli C.... more authors ... less authors ( BioMed Central Ltd , 2021 , Article)The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malignancies, ... -
Potential of Stem Cell-Based Therapy for Ischemic Stroke.
Marei, Hany E; Hasan, A; Rizzi, R; Althani, A; Afifi, N; Cenciarelli, C; Caceci, Thomas; Shuaib, Ashfaq... more authors ... less authors ( Frontiers Media , 2018 , Article Review)Ischemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the ... -
The Implementation of an Integrated Management System at Qatar Biobank
Hannigan L.; Deyab G.; Al Thani A.; Al Marri A.; Afifi N. ( Mary Ann Liebert Inc. , 2019 , Article)Qatar Biobank (QBB) is a platform that will make vital health research possible through its collection of samples and information on health and lifestyle from the local population of Qatar. The goal of QBB is to collect, ... -
Therapeutic potential of human olfactory bulb neural stem cells for spinal cord injury in rats.
Marei, H.E.; Althani, A.; Rezk, S.; Farag, A.; Lashen, S.; Afifi, N.; Abd-Elmaksoud, A.; Pallini, R.; Casalbore, P.; Cenciarelli, C.; Caceci, T.... more authors ... less authors ( Nature Publishing Group , 2016 , Article)STUDY DESIGN: Adult human olfactory bulb neural stem cells (OBNSCs) were isolated from human patients undergoing craniotomy for tumor resection. They were genetically engineered to overexpresses green fluorescent protein ...