تصفح حسب المؤلف "n 2011087789"
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Activation of K7 channels with the anticonvulsant retigabine alleviates neuropathic pain behaviour in the streptozotocin rat model of diabetic neuropathy.
Djouhri, Laiche; Malki, MohammedImad; Zeidan, Asad; Nagi, Karim; Smith, Trevor ( Taylor & Francis (Routledge) , 2019 , Article)Diabetic peripheral neuropathy (DPN) is the most incapacitating complication of diabetes mellitus. Up to 50% of patients with DPN develop peripheral neuropathic pain (PNP). The underlying ionic and molecular mechanisms of ... -
Comparison of co-presence of Epstein-Barr virus and high-risk human papillomaviruses in colorectal cancers in the Middle East Region
Nagi, Karim; Gupta, Ishita; Al-Thawadi, Hamda A; Jabeen, Ayesha; Malki, Mohammed I.; Vranic, Semir; Al-Moustafa, Ala-Eddin... more authors ... less authors ( Qatar University Press , 2020 , Poster)Background: Several studies have shown the presence of onco viral DNA in colorectal tumor tissues. Viral infection by onco-viruses such as Human papillomaviruses (HPVs) and Epstein-Barr virus (EBV) are well-known to be ... -
Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation
Mansour, Ahmed; Nagi, Karim; Dallaire, Paul; Lukasheva, Viktoriya; Le Gouill, Christian; Bouvier, Michel; Pineyro, Graciela... more authors ... less authors ( American Chemical Society , 2021 , Article)Prolonged exposure to opioid receptor agonists triggers adaptations in the adenylyl cyclase (AC) pathway that lead to enhanced production of cyclic adenosine monophosphate (cAMP) upon withdrawal. This cellular phenomenon ... -
Copresence of High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer: A Tissue Microarray and Molecular Study from Lebanon
Nagi, Karim; Gupta, Ishita; Jurdi, Nawaf; Yasmeen, Amber; Vranić, Semir; Batist, Gerald; Al Moustafa, Ala-Eddin... more authors ... less authors ( MDPI , 2021 , Article)Colorectal cancer (CRC) is the third most common cause of cancer-related deaths worldwide. Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV) have been reported to be present in different types of human cancers ... -
Detection of β-Arrestin-Mediated G Protein-Coupled Receptor Ubiquitination Using BRET.
Nagi, Karim; Shenoy, Sudha K ( Humana Press, New York, NY , 2019 , Book chapter)Ubiquitination of G protein-coupled receptors (GPCRs) is an important dynamic posttranslational modification that has been linked to the intracellular trafficking of internalized GPCRs to lysosomes. Ubiquitination of GPCRs ... -
Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs
Toth, Krisztian; Nagi, Karim; Slosky, Lauren M.; Rochelle, Lauren; Ray, Caroline; Kaur, Suneet; Shenoy, Sudha K.; Caron, Marc G.; Barak, Larry S.... more authors ... less authors ( American Chemical Society , 2019 , Article)G-protein-coupled receptors (GPCRs) can bias signaling through distinct biochemical pathways that originate from G-protein/receptor and β-arrestin/receptor complexes. Receptor conformations supporting β-arrestin engagement ... -
Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.
Benredjem, Besma; Gallion, Jonathan; Pelletier, Dennis; Dallaire, Paul; Charbonneau, Johanie; Cawkill, Darren; Nagi, Karim; Gosink, Mark; Lukasheva, Viktoryia; Jenkinson, Stephen; Ren, Yong; Somps, Christopher; Murat, Brigitte; Van Der Westhuizen, Emma; Le Gouill, Christian; Lichtarge, Olivier; Schmidt, Anne; Bouvier, Michel; Pineyro, Graciela... more authors ... less authors ( Springer Nature , 2019 , Article)Signaling diversity of G protein-coupled (GPCR) ligands provides novel opportunities to develop more effective, better-tolerated therapeutics. Taking advantage of these opportunities requires identifying which effectors ... -
High-risk human papillomaviruses and Epstein-Barr virus in breast cancer in Lebanese women and their association with tumor grade: a molecular and tissue microarray study.
Nagi, Karim; Gupta, Ishita; Jurdi, Nawaf; Jabeen, Ayesha; Yasmeen, Amber; Batist, Gerald; Vranic, Semir; Al-Moustafa, Ala-Eddin... more authors ... less authors ( BMC , 2021 , Article)High-risk human papillomaviruses (HPVs) are present and can cooperate with Epstein-Barr virus (EBV) to initiate and/or enhance the progression of several types of human carcinomas including cervical as well as head and ... -
High-risk human papillomaviruses and Epstein–Barr virus in breast cancer in Lebanese women and their association with tumor grade: a molecular and tissue microarray study
Nagi, Karim; Gupta, Ishita; Jurdi, Nawaf; Jabeen, Ayesha; Yasmeen, Amber; Batist, Gerald; Vranic, Semir; Al-Moustafa, Ala Eddin... more authors ... less authors ( Springer Nature , 2021 , Article)Background: High-risk human papillomaviruses (HPVs) are present and can cooperate with Epstein–Barr virus (EBV) to initiate and/or enhance the progression of several types of human carcinomas including cervical as well as ... -
How can we improve the measurement of receptor signaling bias?
Nagi, Karim ( Taylor & Francis Group , 2023 , Article)G protein-coupled receptors (GPCRs) are flexible and dynamic signaling entities that can adopt multiple active conformations upon activation [Citation1,Citation2]. However, each agonist stabilizes a distinct receptor ... -
Molecular aspects of delta opioid receptors.
Gendron, Louis; Nagi, Karim; Zeghal, Manel; Giguère, Patrick M; Pineyro, Graciela ( Elsevier , 2019 , Article)The delta opioid receptor (DOP) belongs to the Class A, rhodopsin-like family of G protein-coupled receptors. Although this receptor has a high level of similarity with the other opioid receptors, it displays unique aspects ... -
Signaling diversity of mu- and delta- opioid receptor ligands: Re-evaluating the benefits of β-arrestin/G protein signaling bias.
Pineyro, Graciela; Nagi, Karim ( Elsevier , 2020 , Article)Opioid analgesics are elective for treating moderate to severe pain but their use is restricted by severe side effects. Signaling bias has been proposed as a viable means for improving this situation. To exploit this ... -
Vitamin D and Its Potential Interplay With Pain Signaling Pathways
Habib, Abdella M; Nagi, Karim; Thillaiappan, Nagendra Babu; Akhtar, Saghir; vijayakumar, sukumaran ( Frontiers Media , 2020 , Article Review)About 50 million of the U.S. adult population suffer from chronic pain. It is a complex disease in its own right for which currently available analgesics have been deemed woefully inadequate since ~20% of the sufferers ...