Browsing by Author "n 2012188483"

Now showing items 1-9 of 9

    • A population study of clinically actionable genetic variation affecting drug response from the Middle East 

      Jithesh, Puthen Veettil; Abuhaliqa, Mohammed; Syed, Najeeb; Ahmed, Ikhlak; El Anbari, Mohammed; ... more authors ( Nature Research , 2022 , Article)
      Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is ...

    • Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism. 

      Al-Khelaifi, Fatima; Yousri, Noha A; Diboun, Ilhame; Semenova, Ekaterina A; Kostryukova, Elena S; ... more authors ( Frontiers Media , 2020 , Article)
      The genetic predisposition to elite athletic performance has been a controversial subject due to the underpowered studies and the small effect size of identified genetic variants. The aims of this study were to investigate ...

    • Mendelian inheritance of trimodal CpG methylation sites suggests distal cis-acting genetic effects. 

      Zaghlool, Shaza B; Al-Shafai, Mashael; Al Muftah, Wadha A; Kumar, Pankaj; Gieger, Christian; ... more authors ( BioMed Central , 2016 , Article)
      Environmentally influenced phenotypes, such as obesity and insulin resistance, can be transmitted over multiple generations. Epigenetic modifications, such as methylation of DNA cytosine-guanine (CpG) pairs, may be carriers ...

    • Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance. 

      Al-Khelaifi, Fatima; Diboun, Ilhame; Donati, Francesco; Botre, Francesco; Abraham, David; ... more authors ( Nature Research , 2019 , Article)
      Genetic research of elite athletic performance has been hindered by the complex phenotype and the relatively small effect size of the identified genetic variants. The aims of this study were to identify genetic predisposition ...

    • Metabolic profiling of elite athletes with different cardiovascular demand 

      Al-Khelaifi, Fatima; Donati, Francesco; Botrè, Francesco; Latiff, Aishah; Abraham, David; ... more authors ( John Wiley & Sons Ltd , 2019 , Article)
      Intensive exercise of elite athletes can lead to physiological alterations in the cardiovascular system in response to increased stroke volume and blood pressure, known collectively as cardiovascular demand (CD). This study ...

    • PopPAnTe: population and pedigree association testing for quantitative data. 

      Visconti, Alessia; Al-Shafai, Mashael; Al Muftah, Wadha A; Zaghlool, Shaza B; Mangino, Massimo; ... more authors ( BioMed Central , 2017 , Article)
      Family-based designs, from twin studies to isolated populations with their complex genealogical data, are a valuable resource for genetic studies of heritable molecular biomarkers. Existing software for family-based studies ...

    • Qatar genome: Insights on genomics from the Middle East 

      Mbarek, Hamdi; Devadoss Gandhi, Geethanjali; Selvaraj, Senthil; Al-Muftah, Wadha; Badji, Radja; ... more authors ( Wiley , 2022 , Article)
      Despite recent biomedical breakthroughs and large genomic studies growing momentum, the Middle Eastern population, home to over 400 million people, is underrepresented in the human genome variation databases. Here we ...

    • Signal transducer and activator of transcription 3 (Stat3) suppresses stat1/interferon signaling pathway and inflammation in senescent preadipocytes 

      Madani, Aisha Y.; Majeed, Yasser; Abdesselem, Houari B.; Agha, Maha V.; Vakayil, Muneera; ... more authors ( MDPI , 2021 , Article)
      © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT ...

    • Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes. 

      Madani, Aisha Y; Majeed, Yasser; Abdesselem, Houari B; Agha, Maha V; Vakayil, Muneera; ... more authors ( MDPI , 2021 , Article)
      Obesity promotes premature aging and dysfunction of white adipose tissue (WAT) through the accumulation of cellular senescence. The senescent cells burden in WAT has been linked to inflammation, insulin-resistance (IR), ...