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المؤلفMroueh F.M.
المؤلفNoureldein M.
المؤلفZeidan Y.H.
المؤلفBoutary S.
المؤلفIrani S.A.M.
المؤلفEid S.
المؤلفHaddad M.
المؤلفBarakat R.
المؤلفHarb F.
المؤلفCostantine J.
المؤلفKanj R.
المؤلفSauleau E.-A.
المؤلفOuhtit A.
المؤلفAzar S.T.
المؤلفEid A.H.
المؤلفEid A.A.
تاريخ الإتاحة2020-04-01T06:59:41Z
تاريخ النشر2019
اسم المنشورFASEB journal : official publication of the Federation of American Societies for Experimental Biology
المصدرScopus
الرقم المعياري الدولي للكتاب15306860
معرّف المصادر الموحدhttp://dx.doi.org/10.1096/fj.201900396RR
معرّف المصادر الموحدhttp://hdl.handle.net/10576/13666
الملخصCancer was recently annexed to diabetic complications. Furthermore, recent studies suggest that cancer can increase the risk of diabetes. Consequently, diabetes and cancer share many risk factors, but the cellular and molecular pathways correlating diabetes and colon and rectal cancer (CRC) remain far from understood. In this study, we assess the effect of hyperglycemia on cancer cell aggressiveness in human colon epithelial adenocarcinoma cells in vitro and in an experimental animal model of CRC. Our results show that Nox (NADPH oxidase enzyme) 4-induced reactive oxygen species (ROS) production is deregulated in both diabetes and CRC. This is paralleled by inactivation of the AMPK and activation of the mammalian target of rapamycin (mTOR) C1 signaling pathways, resulting in 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) accumulation, induction of DNA damage, and exacerbation of cancer cell aggressiveness, thus contributing to the genomic instability and predisposition to increased tumorigenesis in the diabetic milieu. Pharmacologic activation of AMPK, inhibition of mTORC1, or blockade of Nox4 reduce ROS production, restore the homeostatic signaling of 8-oxoguanine DNA glycosylase/8-oxodG, and lessen the progression of CRC malignancy in a diabetic milieu. Taken together, our results identify the AMPK/mTORC1/Nox4 signaling axis as a molecular switch correlating diabetes and CRC. Modulating this pathway may be a strategic target of therapeutic potential aimed at reversing or slowing the progression of CRC in patients with or without diabetes.-Mroueh, F. M., Noureldein, M., Zeidan, Y. H., Boutary, S., Irani, S. A. M., Eid, S., Haddad, M., Barakat, R., Harb, F., Costantine, J., Kanj, R., Sauleau, E.-A., Ouhtit, A., Azar, S. T., Eid, A. H., Eid, A. A. Unmasking the interplay between mTOR and Nox4: novel insights into the mechanism connecting diabetes and cancer.
اللغةen
الناشرNLM (Medline)
الموضوعcolorectal cancer
DNA damage
mTORC1
NADPH oxidases
العنوانUnmasking the interplay between mTOR and Nox4: novel insights into the mechanism connecting diabetes and cancer
النوعArticle
الصفحات14051-14066
رقم العدد12
رقم المجلد33
dc.accessType Open Access


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