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Naked Poly(amidoamine) Dendrimer Nanoparticles Exhibit Intrinsic Embryotoxicity During the Early Stages of Normal Development.
(
American Science Publishers ASP
, 2020 , Article)
To investigate the impact of poly(amidoamine) dendrimers (PAMAMs) in the embryo, we explored the outcome of different generations (G₄ and G) on the early stages of embryogenesis using the chicken embryo as a model. We also ...
Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
(
Elsevier
, 2021 , Article)
HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) ...
In Vivo Evaluation of Taste-Masked Fast-Disintegrating Sublingual Tablets of Epinephrine Microcrystals
(
Springer New York LLC
, 2018 , Article)
n community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets ...
Epinephrine in anaphylaxis: Preclinical study of pharmacokinetics after sublingual administration of taste-masked tablets for potential pediatric use
(
MDPI AG
, 2018 , Article)
Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose of epinephrine is injected from an auto-injector (EAI). Needle phobia highly contributes to EAI underuse, leading to ...
Development of a college-level assessment framework in line with international accreditation standards: A Middle Eastern perspective.
(
Elsevier
, 2017 , Article)
Accreditation of international pharmacy programs by North American and European accrediting bodies is becoming increasingly popular. Practices regarding assessment and evaluation are especially highlighted in accreditation ...
Pharmaceutical Characterization of MyoNovin, a Novel Skeletal Muscle Regenerator: in silico, in vitro and in vivo Studies.
(
Canadian Society for Pharmaceutical Sciences
, 2018 , Article)
MyoNovin is a novel skeletal muscle-regenerating compound developed through synthesis of two nitro groups onto a guaifenesin backbone to deliver nitric oxide to skeletal muscle with a potential to treat muscle atrophy. The ...
Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential
(
Elsevier
, 2021 , Article)
Drug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue or cellular level. However, emerging ...
A systematic review of stability of medicines used in emergency medical service settings
(
Hamad bin Khalifa University Press (HBKU Press)
, 2020 , Article)
Background: Temperature, among several environment conditions like humidity, is known to impact medicine stability 1,2 . In emergency medical service (EMS) settings, it is often challenging to control these conditions. In ...
Monitoring temperature and humidity in ambulance service rapid-response vehicles and paramedics medication bags: A pilot study
(
Hamad bin Khalifa University Press (HBKU Press)
, 2022 , Article)
Background: In the pre-hospital context, paramedics carry medications in multi-compartment medication bags. However, these medications are occasionally subjected to temperature and humidity variations as they are being ...
PLGA-Gold Nanocomposite: Preparation and Biomedical Applications
(
MDPI
, 2022 , Article)
A composite system consisting of both organic and inorganic nanoparticles is an approach
to prepare a new material exhibiting “the best of both worlds”. In this review, we highlight the
recent advances in the preparation ...