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Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway
(
Elsevier
, 2020 , Article)
Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that has been proposed as a strong sustainer and promoter of tumorigenesis and ...
Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling.
(
Frontiers Media
, 2019 , Article)
Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and studies. However, the anticancer potential of SNG is yet to be established in multiple myeloma (MM), a ...
Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk.
(
Frontiers Media
, 2019 , Article)
The ability of epithelial cells to organize through cell-cell adhesion into a functioning epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent cells are made up of tight junctions ...
Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species.
(
MDPI
, 2020 , Article)
Sanguinarine (SNG), a natural compound with an array of pharmacological activities, has promising therapeutic potential against a number of pathological conditions, including malignancies. In the present study, we have ...
A novel approach of encapsulating curcumin and succinylated derivative in mannosylated-chitosan nanoparticles
(
Elsevier
, 2022 , Article)
Curcumin (CUR) manifests anti-colon cancer activity but suffers from low solubility, bioavailability, and instability, rendering it not as effective as its chemotherapeutic cousins. Here, we conjugate CUR to succinic ...
The effect of migration on the incidence of new-onset metabolic syndrome in migrants to Qatar
(
Hamad bin Khalifa University Press (HBKU Press)
, 2022 , Article)
Background: There is substantial evidence that migration to Western countries is associated with an increased risk of metabolic syndrome (MetS) 1 . However, there is a paucity of data on the incidence of MetS in migrants ...
The potential role of vitamin C in empowering cancer immunotherapy
(
Elsevier
, 2022 , Article)
Vitamin C also known as L-ascorbic acid is a nutrient naturally occurring in many fruits and vegetables and widely known for its potent antioxidant activity. Several studies have highlighted the importance of using high ...
Thiostrepton inhibits growth and induces apoptosis by targeting FoxM1/SKP2/MTH1 axis in B-precursor acute lymphoblastic leukemia cells
(
Taylor and Francis Group
, 2021 , Article)
Forkhead box M1 (FoxM1) is a transcription factor that plays an important role in the etiology of many cancers, however, its role has not been elucidated in B-precursor acute lymphoblastic leukemia (B-pre-ALL). In the ...
Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids
(
Elsevier
, 2021 , Article)
Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of human diseases including cancer. In this line, now it has become evident that ROS level/concentration is a major factor in the growth, ...
Natural resorcylic acid lactones: A chemical biology approach for anticancer activity
(
Elsevier
, 2022 , Article)
Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including ...