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Can atorvastatin with metformin change the natural history of prostate cancer as characterized by molecular, metabolomic, imaging and pathological variables? A randomized controlled trial protocol
(
Elsevier
, 2016 , Article)
Background Atorvastatin and metformin are known energy restricting mimetic agents that act synergistically to produce molecular and metabolic changes in advanced prostate cancer (PCa). This trial seeks to determine whether ...
Potential Novel Therapy Targets in Neuroendocrine Carcinomas of the Breast.
(
Elsevier
, 2018 , Article)
Neuroendocrine carcinoma (NEC) of the breast is a rare, special type of breast cancer, reportedly constituting 2% to 5% of all breast cancers. Although breast NEC does not have a specific targeted therapy, several new ...
Glycan analysis as biomarkers for testicular cancer
(
MDPI AG
, 2019 , Article Review)
The U.S. Preventive Services Task Force does not recommend routine screening for testicular cancer (TC) in asymptomatic men, essentially because serological testicular cancer (TC) biomarkers are not reliable. The main ...
Geochemical investigation of Yamama crude oils and their inferred source rocks in the Mesopotamian Basin, Southern Iraq
(
Taylor & Francis
, 2019 , Article)
Ten oil samples from the Yamama reservoirs and ten extracts of purported source rocks from sixteen wells in the Mesopotamian Basin, Southern Iraq have been analyzed using GC, GC/MS and Stable Carbon Isotope. Yamama oils ...
Integrated datasets of proteomic and metabolomic biomarkers to predict its impacts on comorbidities of type 2 diabetes mellitus
(
Dove Medical Press
, 2020 , Article)
© 2020 Cheema et al. Objective: The objective of the current study is to accomplish a relative exploration of the biological roles of differentially dysregulated genes (DRGs) in type 2 diabetes mellitus (T2DM). The study ...
BRIP1 overexpression is correlated with clinical features and survival outcome of luminal breast cancer subtypes
(
BioScientifica Ltd.
, 2018 , Article)
In Oman, breast cancer is most common, representing approximately more than 25% of all cancers in women. Relatively younger populations of patients (25-40 years) present surprisingly with an aggressive phenotype and advanced ...
iTRAQ-based quantitative protein expression profiling and MRM verification of markers in type 2 diabetes.
(
American Chemical Society
, 2012 , Article)
The pathogenesis of Type 2 diabetes mellitus (T2DM) is complex owing to molecular heterogeneity in the afflicted population. Current diagnostic methods rely on blood glucose measurements, which are noninformative with ...
The identification of highly upregulated genes in claudin-low breast cancer through an integrative bioinformatics approach
(
Elsevier
, 2020 , Article)
Breast cancer (BC) is one of the leading causes of cancer-related death among women worldwide, and claudin-low breast cancer (CLBC) is a subtype of BC that remains poorly described. This study aimed to identify upregulated ...
Geochemical investigation of Yamama crude oils and their inferred source rocks in the Mesopotamian Basin, Southern Iraq
(
Taylor and Francis Inc.
, 2019 , Article)
Ten oil samples from the Yamama reservoirs and ten extracts of purported source rocks from sixteen wells in the Mesopotamian Basin, Southern Iraq have been analyzed using GC, GC/MS and Stable Carbon Isotope. Yamama oils ...
Prostate-specific antigen glycoprofiling as diagnostic and prognostic biomarker of prostate cancer
(
Royal Society Publishing
, 2019 , Article Review)
The initial part of this review details the controversy behind the use of a serological level of prostate-specific antigen (PSA) for the diagnostics of prostate cancer (PCa). Novel biomarkers are in demand for PCa diagnostics, ...