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المؤلفMothanna Sadiq, Al-Qubaisi
المؤلفAl-Abboodi, Ashwaq Shakir
المؤلفAlhassan, Fatah H.
المؤلفHussein-Al-Ali, Samer
المؤلفFlaifel, Moayad Husein
المؤلفEid, Eltayeb E.M.
المؤلفAlshwyeh, Hussah Abdullah
المؤلفHussein, Mohd Zobir
المؤلفAlnasser, Sulaiman Mohammed
المؤلفSaeed, Mohammed Ibrahim
المؤلفRasedee, Abdullah
المؤلفIbrahim, Wisam Nabeel
تاريخ الإتاحة2022-02-22T05:56:15Z
تاريخ النشر2022-02-07
اسم المنشورSaudi Pharmaceutical Journal
المعرّفhttp://dx.doi.org/10.1016/j.jsps.2022.02.002
الاقتباسAl-Qubaisi, M. S., Al-Abboodi, A. S., Alhassan, F. H., Hussein-Al-Ali, S., Flaifel, M. H., Eid, E. E., ... & Ibrahim, W. N. (2022). Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite. Saudi Pharmaceutical Journal.
الرقم المعياري الدولي للكتاب13190164
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S1319016422000408
معرّف المصادر الموحدhttp://hdl.handle.net/10576/27354
الملخصIn this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without sodium tripolyphosphate. The TQ-NCs were characterized and their anti-inflammatory determined by the response of the LPS-stimulated macrophage RAW 264.7 cells in the production of nitric oxide, prostaglandin E2, tumor necrosis factor-α, interleukin-6, and interleukin-1β. The physicochemical properties of TQ-NC were determined using different machines. TQ was fully incorporated in the highly thermal stable nanoparticles. The nanoparticles showed rapid release of TQ in the acidic medium of the gastric juice. In medium of pH 6.8, TQ-NC exhibited sustained release of TQ over a period of 100 h. The results suggest that TQ-NC nanoparticles have potential application as parenterally administered therapeutic compound. TQ-NC effectively reduce production of inflammatory cytokines by the LPS-stimulated RAW 264.7 cells, indicating that they have anti-inflammatory properties. In conclusion, TQ-NC nanoparticles have the characteristics of efficient carrier for TQ and an effective anti-inflammatory therapeutic compound.
راعي المشروعThe publication of this article was funded by the Qatar National Library.
اللغةen
الناشرElsevier
الموضوعNanocomposite
High-pressure homogenizer
Drug release
RAW 264.7 cells
Inflammatory mediators
العنوانPreparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite
النوعArticle
Open Access user License http://creativecommons.org/licenses/by/4.0/


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