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السجلات المعروضة 1172 -- 1191 من 1320
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Targeted and systemic insights into the crosstalk between DNA-dependent protein kinase catalytic subunit and receptors of estrogen, progesterone and epidermal growth factor in the context of cancer
( Springer , 2021 , Article)DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has emerged as a regulator of carcinogenesis. Increased expression of DNA-PKcs correlates with metastatic cancers. Here we review recently reported crosstalk of ... -
Targeted delivery of rifampicin to tuberculosis-infected macrophages: design, in-vitro, and in-vivo performance of rifampicin-loaded poly(ester amide)s nanocarriers
( Elsevier B.V. , 2016 , Article)We have developed a nano drug delivery system for the treatment of tuberculosis (TB) using rifampicin (RF) encapsulated in poly(ester amide)s nanoparticles (PEA-RF-NPs), which are biocompatible polymers. In this study, ... -
Targeted immunotherapy with a checkpoint inhibitor in combination with chemotherapy: A new clinical paradigm in the treatment of triple-negative breast cancer.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2019 , Article Review)The treatment of several solid and hematologic malignancies with immune checkpoint inhibitors (against PD-1/PD-L1) has dramatically changed the cancer treatment paradigm. However, no checkpoint inhibitors were previously ... -
Targeting DNA Repair Pathways in Hematological Malignancies.
( MDPI , 2020 , Article Review)DNA repair plays an essential role in protecting cells that are repeatedly exposed to endogenous or exogenous insults that can induce varying degrees of DNA damage. Any defect in DNA repair mechanisms results in multiple ... -
Targeting HER2 expression in cancer: New drugs and new indications.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2020 , Article)Functional activation of human epidermal growth factor receptor 2 (HER2) has been shown to strongly promote carcinogenesis, leading to the investigation of HER2-directed agents in cancers with HER2 genomic alterations. ... -
Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways.
( Springer Nature , 2024 , Article)Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, including breast ... -
Targeting inflammatory components in neuropathic pain: The analgesic effect of thymulin related peptide
( Elsevier Ireland Ltd , 2019 , Article Review)Neuropathic pain is considered to be pathological in nature and has been shown to involve, at least partially, dysregulated inflammatory processes. It is a severe chronic disease that can develop following lesions to the ... -
Taxonomy of communications in the operating room
( Springer Verlag , 2018 , Conference Paper)US hospitals are facing critical problems of nurse shortage. One report predicts that there will be a shortage of 260,000 registered nurses by 2025 in the USA, and it was found out that patient mortality risk is 6% higher ... -
Teaching benign paroxysmal positional vertigo to emergency medicine residents by using gagne’s nine steps of instructional design
( Taylor & Francis Group , 2021 , Article)Introduction: Patients commonly seek medical advice with dizziness symptoms. One of the common subtypes of dizziness is benign paroxysmal positional vertigo (BPPV). The American Academy of Neurology recommends that physicians ... -
Teaching Musculoskeletal Module using dissection videos: feedback from medical students.
( BMC , 2021 , Article)Over the last two decades many medical schools have been exploring alternatives to hands-on cadaver dissection in teaching anatomy. This study aimed at reporting medical students' feedback on using dissection videos in ... -
TERT gene fusions characterize a subset of metastatic Leydig cell tumors
( Elsevier , 2021 , Article)Objective: Metastatic Leydig cell tumors (LCT) are rare, difficult to treat malignancies without known underlying molecular-genetic events. An index case of metastatic LCT showed an LDLR-TERT gene fusion upon routine genetic ... -
Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study
( Taylor and Francis Ltd. , 2023 , Article)Functional hypogonadism is a condition characterized by low testosterone concentrations, occurring more commonly in men as they age. The International Prostate Symptom Score (IPSS) is used to categorize the severity of ... -
Teucrium Polium Plant Extract Provokes Substantial Cytotoxicity at the Early Stage of Embryonic Development.
( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2019 , Article)The aim of this study is to explore the outcome of Teucrium polium (TP) medicinal plant consumption on the early stage of fetal development. We used the chicken embryo at 3 days of incubation as a model to evaluate the ... -
The 4-hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions
( Spandidos Publications , 2018 , Article)Lipid peroxidation is associated with several metabolic diseases. Lipid peroxidation causes cellular damage through reactive aldehyde species such as 4-hydroxyonenal (4-HNE). The exact mechanism(s) by which 4-HNE causes ... -
The Arabic Questionnaire for Psychotic Experiences in patients with psychotic disorders: a clinical validation
( BioMed Central Ltd , 2023 , Article)Background: Psychotic experiences are reported in the general population. The Questionnaire for Psychotic Experiences (QPE) was created to test the phenomenological features of these experiences and compare them with those ... -
The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis
( Springer Science and Business Media B.V. , 2023 , Article Review)Background and Aim The impact of multiple risk factors on COVID-19 mortality has been previously reported in multiple systematic reviews and meta-analyses. The aim of this review is to provide a comprehensive update on ... -
The attitude and knowledge of pediatricians and family physicians toward COVID-19 vaccination in children: A cross-sectional study
( Taylor and Francis Ltd. , 2023 , Article)COVID-19 vaccines to children are expected to reduce the transmission of the disease to high-risk groups and achieve herd immunity in younger populations. A positive attitude toward COVID-19 vaccination in children among ... -
The coincidence of increased risk of atrial fibrillation in randomized control trials of omega-3 fatty acids: a meta-analysis
( Taylor and Francis Ltd. , 2021 , Article)[No abstract available] -
The Combination of Dasatinib and PD L1 inhibitor prevents the progression of epithelial mesenchymal transition and dramatically blocks cell invasion of HER2 positive breast cancer cells
( Qatar University Press , 2021 , Poster)Introduction: Both Dasatinib (DA), a tyrosine kinase inhibitor that is used for targeted cancer therapy, and programmed death-ligand 1 (PD-1/PD-L1) inhibitor that is an immune checkpoint therapy, play a vital role in the ... -
The Contemporary Role of Hematopoietic Stem Cell Transplantation in the Management of Chronic Myeloid Leukemia: Is It the Same in All Settings?
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)Hematopoietic stem cell transplantation (HSCT) for chronic myeloid leukemia (CML) patients has transitioned from the standard of care to a treatment option limited to those with unsatisfactory tyrosine kinase inhibitor ...
