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The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.
(
Springer Nature
, 2020 , Article)
Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, ...
Targeting HER2 expression in cancer: New drugs and new indications.
(
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
, 2020 , Article)
Functional activation of human epidermal growth factor receptor 2 (HER2) has been shown to strongly promote carcinogenesis, leading to the investigation of HER2-directed agents in cancers with HER2 genomic alterations. ...
اسم (الرحمن) في القرآن، الدلالة والسياق: دراسة موضوعية
(
BRILL
, 2020 , Article)
This paper examines one of Allah’s names (Al-Raḥmān, the Merciful), and the unique
manner in which it appears within some verses, in contexts that do not reflect its
meaning – derived from ‘Mercy’. In light of multiple ...
Development of the international cardiac rehabilitation registry data dictionary using a Delphi process
(2020 , Conference Paper)
Background: Cardiac rehabilitation (CR) registries are a powerful tool for improvement
of care quality, and consequently patients’ outcomes. However, there are few CR registries
worldwide, with Canada’s currently being ...
Economic Evaluations of CYP2C19 Genotype-Guided Antiplatelet Therapy Compared to the Universal Use of Antiplatelets in Patients With Acute Coronary Syndrome: A Systematic Review.
(
SAGE Publications
, 2020 , Article)
Clopidogrel is widely used after the percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and requires activation by cytochrome P450 (CYP), primarily CYP2C19. Patients with CYP2C19 ...
العلاقة بين التفسير بالرأي والهدايات
(
مركز بحوث القرآن - جامعة ملايا، ماليزيا
(Centre of Quranic Research (CQR), University of Malaya)
, 2020 , Article)
يناقش هذا البحث طبيعة العلاقة بين التفسير بالرأي وموضوع هدايات القرآن، فلا شك أنّ مِن مقاصد إنزال القرآن تدبره: "كتاب أنزلناه إليك مبارك ليدّبّروا آياته، وليتذكر أولو الألباب"، وحين بيّن الله تعالى وظيفة النبي في بيان ...
EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: and Rat Studies.
(
American Chemical Society
, 2020 , Article)
Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of the PTEN/Akt/FoxO3a ...
Willingness to participate in genome testing: a survey of public attitudes from Qatar
(
Springer
, 2020 , Article)
Genomics has the potential to revolutionize medical approaches to disease prevention, diagnosis, and treatment, but it does not come without challenges. The success of a national population-based genome program, like the ...
Implementation models: applicability across research, implementation, culture and context
(
University of Adelaide, Joanna Briggs Institute
, 2020 , Article)
The Joanna Briggs Institute (JBI) Model for Evidencebased
Healthcare is a whole-of-health model that brings
together healthcare needs, research generation, synthesis,
transfer and implementation while accounting ...
Degradation of hydroxychloroquine by electrochemical advanced oxidation processes
(
Elsevier
, 2020 , Article)
In this work, the degradation of hydroxychloroquine (HCQ) drug in aqueous solution by electrochemical advanced oxidation processes including electrochemical oxidation (EO) using boron doped diamond (BDD) and its combination ...