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A Review of the Clinical Pharmacokinetics and Pharmacodynamics of Isavuconazole
(
Springer-Verlag France
, 2018 , Article Review)
Invasive fungal infections are a major cause of morbidity and mortality, especially for immunocompromised patients. Treatment options are few and most are limited by safety and formulation concerns. Isavuconazole is a new ...
Retinopathy of Type 1 Diabetes in Arab Countries: Systematic Review and Meta-Analysis.
(
Karger
, 2018 , Article Review)
To conduct a systematic review and meta-analysis of retinopathy prevalence in patients with type 1 diabetes (T1D) in 22 Arab countries. We systematically searched 4 different literature databases (PubMed, Science Direct, ...
Novel CD44-downstream signaling pathways mediating breast tumor invasion
(
Ivyspring International Publisher
, 2018 , Article Review)
CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell
and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways,
including ...
Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine.
(
Nature Research
, 2018 , Article Review)
The gene-environment interactions resulting from famine and the subsequent increased intergenerational risk of type 2 diabetes mellitus (T2DM) have contributed to the current epidemic of T2DM in China, which poses major ...
The Dual Specificity Role of Transcription Factor FOXO in Type 2-diabetes and Cancer
(
Bentham Science Publishers
, 2018 , Article Review)
The FOXO (Forkhead box O) transcription factors are implicated in several signaling pathways and play a vital role in various cellular and physiological processes include for instance, ROS (reactive oxygen species) response, ...
Epstein-Barr Virus in Gliomas: Cause, Association, or Artifact?
(
Frontiers Media
, 2018 , Article Review)
Gliomas are the most common malignant brain tumors and account for around 60% of all primary central nervous system cancers. Glioblastoma multiforme (GBM) is a grade IV glioma associated with a poor outcome despite recent ...
Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the Initiation of Epithelial-Mesenchymal Transition and Cancer Progression.
(
Frontiers Media
, 2018 , Article Review)
Oncoviruses are implicated in around 20% of all human cancers including both solid and non-solid malignancies. Epstein-Barr virus (EBV) and human papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, ...
Design for sustainable manufacturing: Approach, implementation, and assessment
(
MDPI AG
, 2018 , Article Review)
The implementation of sustainable systems is an essential requirement in modern manufacturing, in order to minimize the environmental and health concerns, and conserves energy and natural resources. The sustainable ...
Effects of acute and chronic exercise on immunological parameters in the elderly aged: Can physical activity counteract the effects of aging?
(
Frontiers Media S.A.
, 2018 , Article Review)
Immunosenescence is characterized by deterioration of the immune system caused by aging which induces changes to innate and adaptive immunity. Immunosenescence affects function and phenotype of immune cells, such as ...
The Role of Epstein-Barr Virus in Cervical Cancer: A Brief Update.
(
Frontiers Media
, 2018 , Article Review)
Epstein-Barr virus (EBV) belongs to the group of gamma-herpes viruses and was the first recognized human oncovirus. EBV is responsible for infectious mononucleosis and multiple lymphoid and epithelial malignancies including ...