تصفح Pharmacy Research حسب المؤلف "Parray, Aijaz"
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Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients
Akbar, Shayista; Raza, Afsheen; Mohsin, Reyad; Kanbour, Aladdin; Qadri, Shahnaz; Parray, Aijaz; Zar Gul, Abdul Rehman; Philip, Anite; Vijayakumar, Suma; Merhi, Maysaloun; Hydrose, Shereena; Inchakalody, Varghese Philipose; Al-Abdulla, Rajaa; Abualainin, Wafa; Sirriya, Shaza Abu; Al-Bozom, Issam; Uddin, Shahab; Khan, Omar Muhammad; Mohamed Ibrahim, Mohamed Izham; Al Homsi, Ussama; Dermime, Said... more authors ... less authors ( Frontiers Media S.A. , 2023 , Article)Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treatment outcomes of NSCLC patients with better overall survival. However, 15-40% of the patients still ... -
Circulating microparticles as biomarkers of stroke: A focus on the value of endothelial- and platelet-derived microparticles.
El-Gamal, Heba; Parray, Aijaz S; Mir, Fayaz A; Shuaib, Ashfaq; Agouni, Abdelali ( Wiley , 2019 , Article)Stroke is one of the leading causes of mortality and disability worldwide. Numerous pathophysiological mechanisms involving blood vessels, coagulation and inflammation contribute to the vascular occlusion. Perturbations ... -
Complement C5a and Clinical Markers as Predictors of COVID-19 Disease Severity and Mortality in a Multi-Ethnic Population
Cyprian, Farhan S.; Suleman, Muhammad; Abdelhafez, Ibrahim; Doudin, Asmma; Masud Danjuma, Ibn Mohammed; Mir, Fayaz Ahmad; Parray, Aijaz; Yousaf, Zohaib; Siddiqui, Mohammed Yaseen Ahmed; Abdelmajid, Alaaedin; Mulhim, Mohammad; Al-Shokri, Shaikha; Abukhattab, Mohammad; Shaheen, Ranad; Elkord, Eyad; Al-khal, Abdul Latif; Elzouki, Abdel Naser; Girardi, Guillermina... more authors ... less authors ( Frontiers Media S.A. , 2021 , Article)Coronavirus disease-2019 (COVID-19) was declared as a pandemic by WHO in March 2020. SARS-CoV-2 causes a wide range of illness from asymptomatic to life-threatening. There is an essential need to identify biomarkers to ... -
Corneal nerve loss in patients with TIA and acute ischemic stroke in relation to circulating markers of inflammation and vascular integrity
Khan, Adnan; Parray, Aijaz; Akhtar, Naveed; Agouni, Abdelali; Kamran, Saadat; Pananchikkal, Sajitha V.; Priyanka, Ruth; Gad, Hoda; Ponirakis, Georgios; Petropoulos, Ioannis N.; Chen, Kuan-Han; Tayyab, Kausar; Saqqur, Maher; Shuaib, Ashfaq; Malik, Rayaz A.... more authors ... less authors ( Nature Research , 2022 , Article)Vascular and inflammatory mechanisms are implicated in the development of cerebrovascular disease and corneal nerve loss occurs in patients with transient ischemic attack (TIA) and acute ischemic stroke (AIS). We have ... -
Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders
Abdelsam, Shahenda Salah; Ghanem, Sarah Khalaf; Zahid, Muhammad Ammar; Abunada, Hanan H.; Bader, Loulia; Raïq, Hicham; Khan, Abbas; Parray, Aijaz; Djouhri, Laiche; Agouni, Abdelali... more authors ... less authors ( Wiley , 2024 , Article Review)RNA-binding proteins (RBPs) play a crucial role in the regulation of posttranscriptional RNA networks, which can undergo dysregulation in many pathological conditions. Human antigen R (HuR) is a highly researched RBP that ... -
Influence of the Aryl Hydrocarbon Receptor Activating Environmental Pollutants on Autism Spectrum Disorder
Dhulkifle, Hevna; Agouni, Abdelali; Zeidan, Asaad; Al-Kuwari, Mohammed Saif; Parray, Aijaz; Tolefat, Mohamed; Korashy, Hesham M.... more authors ... less authors ( MDPI , 2021 , Article Review)Autism spectrum disorder (ASD) is an umbrella term that includes many different disorders that affect the development, communication, and behavior of an individual. Prevalence of ASD has risen exponentially in the past ... -
Letter to the Editor Response
Abdul, Salam; Kamran, Sadat; Bibi, Rubina; Korashy, Hesham M.; Parray, Aijaz; Mannai, Adbulla Al; Ansari, Abdulrahman Al; Kanikicharla, Krishna Kumar; Gashi, Arta Zogaj; Shuaib, Ashfaq... more authors ... less authors ( Elsevier , 2020 , Other)To the Editor We thank Dr. Luis Rafael Moscote-Salazar and Dr. Amit Agrawal for their interest in our recently published article in the Journal.1 The authors do not raise any concerns about the scientific facts and the ... -
Molecular Mechanisms Underpinning Microparticle-Mediated Cellular Injury in Cardiovascular Complications Associated with Diabetes.
Benameur, Tarek; Osman, Aisha; Parray, Aijaz; Ait Hssain, Ali; Munusamy, Shankar; Agouni, Abdelali... more authors ... less authors ( Hindawi , 2019 , Article)Microparticles (MPs) are small vesicles shed from the cytoplasmic membrane of healthy, activated, or apoptotic cells. MPs are very heterogeneous in size (100-1,000 nm), and they harbor proteins and surface antigens specific ... -
Sestrin2 as a Protective Shield against Cardiovascular Disease
Zahid, Muhammad Ammar; Abdelsalam, Shahenda Salaheldin; Raïq, Hicham; Parray, Aijaz; Korashy, Hesham Mohamed; Zeidan, Asad; Elrayess, Mohamed A.; Agouni, Abdelali... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)A timely and adequate response to stress is inherently present in each cell and is important for maintaining the proper functioning of the cell in changing intracellular and extracellular environments. Disruptions in the ... -
Sestrin2 suppression aggravates oxidative stress and apoptosis in endothelial cells subjected to pharmacologically induced endoplasmic reticulum stress
Fatima, Munazza T; Hasan, Maram; Abdelsalam, Shahenda S; Sivaraman, Siveen K; El-Gamal, Heba; Zahid, Muhammad A; Elrayess, Mohamed A; Korashy, Hesham M; Zeidan, Asad; Parray, Aijaz S; Agouni, Abdelali... more authors ... less authors ( Elsevier , 2021 , Article)Endoplasmic reticulum (ER) stress is an inflammatory response that contributes to endothelial dysfunction, a hallmark of cardiovascular diseases, in close interplay with oxidative stress. Recently, Sestrin2 (SESN2) emerged ... -
There Is Selective Increase in Pro-thrombotic Circulating Extracellular Vesicles in Acute Ischemic Stroke and Transient Ischemic Attack: A Study of Patients From the Middle East and Southeast Asia.
Agouni, Abdelali; Parray, Aijaz S; Akhtar, Naveed; Mir, Fayaz A; Bourke, Paula J; Joseph, Sujata; Morgan, Deborah M; Santos, Mark D; Wadiwala, Muhammad F; Kamran, Saadat; Sivaraman, Siveen K; Shuaib, Ashfaq... more authors ... less authors ( Frontiers Media , 2019 , Article)Stroke attacks were found to be present at a younger age in patients from Southeast Asia (SE) and the Middle East (ME) resident in the state of Qatar. Extracellular vesicles (EVs), which are small membrane vesicles with ...