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Na + /H + exchanger isoform 1-induced osteopontin expression facilitates cardiac hypertrophy through p90 ribosomal S6 kinase
(
NLM (Medline)
, 2018 , Article)
Cardiovascular diseases are the leading cause of death worldwide. One in three cases of heart failure is due to dilated cardiomyopathy. The Na+/H+ exchanger isoform 1 (NHE1), a multifunctional protein and the key pH regulator ...
Diabetes care in Qatar: a survey of pharmacists’ activities, attitudes and knowledge
(
Springer Netherlands
, 2018 , Article)
Background Diabetes mellitus is recognized as a major public health issue and is one of the top ten causes of death in Qatar. Objective To describe the activities, and attitudes of Qatar pharmacists toward diabetes, to ...
Preparation and optimization of monodisperse polymeric microparticles using modified vibrating orifice aerosol generator for controlled delivery of letrozole in breast cancer therapy
(
Taylor and Francis Ltd.
, 2018 , Article)
Letrozole (LTZ) is effective for the treatment of hormone-receptor-positive breast cancer in postmenopausal women. In this work, and for the first time, using vibrating orifice aerosol generator (VOAG) technology, monodisperse ...
Design and Interpretation of Noninferiority Trials
(
Springer New York LLC
, 2018 , Article)
[No abstract available]
Fixed-dose combination associated with faster time to smear conversion compared to separate tablets of anti-tuberculosis drugs in patients with poorly controlled diabetes and pulmonary tuberculosis in Qatar
(
BioMed Central Ltd.
, 2018 , Article)
Background: Diabetes is associated with increased risk of tuberculosis (TB) treatment failure, death, and relapse compared to patients without diabetes. Current TB regimens are available as fixed dose combination (FDC) and ...
Pharmaceutical Characterization of MyoNovin, a Novel Skeletal Muscle Regenerator: in silico, in vitro and in vivo Studies.
(
Canadian Society for Pharmaceutical Sciences
, 2018 , Article)
MyoNovin is a novel skeletal muscle-regenerating compound developed through synthesis of two nitro groups onto a guaifenesin backbone to deliver nitric oxide to skeletal muscle with a potential to treat muscle atrophy. The ...
Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines
(
Frontiers Media S.A.
, 2018 , Article)
Therapeutic agents used in the treatment of cancer are known to develop resistance against cancer cells. Hence, there is a continuing need to investigate novel agents for the treatment and management of cancer. Antitumor ...
Smoking cessation intervention: Can diabetic patients? change their motivation to quit and nicotine dependence?
(
Pharmainfo Publications
, 2018 , Article)
Introduction: Considering smoking tobacco is a bad habit that drive smokers to nicotine dependence; that argue an urgent need to evaluate factors keep them smoke and how a smoking cessation intervention can affect these ...
Evaluating the effect of glycaemic control, blood pressure, lipid profile and diabetes duration on developing diabetes complications and its progression
(
Pharmainfo Publications
, 2018 , Article)
Purpose: This study was aimed to evaluate the effect of glycaemic control, blood pressure, lipid profile and diabetes duration on developing diabetes complications and its progression. Methods: One thousand and fourteen ...
Do community pharmacists in Qatar manage acute respiratory conditions rationally? A simulated client study
(
Blackwell Publishing Ltd
, 2018 , Article)
Objectives: This study evaluated Qatar's community pharmacists' therapeutic recommendations, medication labelling, dispensing and counselling practices in response to common cold and allergic rhinitis symptoms. Methods: A ...