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Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model.
(
MDPI
, 2022 , Article)
Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells' proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their ...
Correction to: Lead nitrate induces inflammation and apoptosis in rat lungs through the activation of NF‑κB and AhR signaling pathways (Environmental Science and Pollution Research, (2022), 29, 43, (64959-64970), 10.1007/s11356-022-19980-8)
(
Springer
, 2022 , Article)
The sizing of images Figs. 3 and 4 is modified in the original published proof. The Original article has been corrected.
Lead Nitrate Induces Inflammation and Apoptosis in Rat Lungs Through the Activation of NF-κB and AhR Signaling Pathways
(
Springer
, 2022 , Article)
Lead (Pb) is one of the most frequent hazardous air contaminants, where the lungs are particularly vulnerable to its toxicity. However, the Pb distribution and its impact on lung inflammation/apoptosis and particularly the ...
Role of RAS signaling in ovarian cancer
(
Taylor & Francis
, 2022 , Article)
The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS, especially KRAS mutational status at codons 12, 13, and ...
Crosstalk between aryl hydrocarbon receptor (AhR) and BCL-2 pathways suggests the use of AhR antagonist to maintain normal differentiation state of mammary epithelial cells during BCL-2 inhibition therapy
(
Elsevier
, 2022 , Article)
IntroductionActivating the aryl hydrocarbon receptor upon exposure to environmental pollutants promotes development of breast cancer stem cell (CSCs). BCL-2 family proteins protect cancer cells from the apoptotic effects ...
A novel approach of encapsulating curcumin and succinylated derivative in mannosylated-chitosan nanoparticles
(
Elsevier
, 2022 , Article)
Curcumin (CUR) manifests anti-colon cancer activity but suffers from low solubility, bioavailability, and instability, rendering it not as effective as its chemotherapeutic cousins. Here, we conjugate CUR to succinic ...
Aryl Hydrocarbon Receptor Promotes Cell Growth, Stemness Like Characteristics, and Metastasis in Human Ovarian Cancer via Activation of PI3K/Akt, β-Catenin, and Epithelial to Mesenchymal Transition Pathways
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2022 , Article)
Ovarian cancer (OC) ranks first in cancer-related deaths out of all female reproductive malignancies with high-pitched tumor relapse and chemoresistance. Several reports correlate cancer occurrences with exposure to ...