The effect of nuts consumption on circulating oxidized low-density lipoproteins: A systematic review and meta-analysis of randomized controlled trials.
| Author | Abbasifard, Mitra |
| Author | Jamialahmadi, Tannaz |
| Author | Reiner, Željko |
| Author | Eid, Ali H |
| Author | Sahebkar, Amirhossein |
| Available date | 2023-03-05T06:27:21Z |
| Publication Date | 2023-03-01 |
| Publication Name | Phytotherapy Research |
| Identifier | http://dx.doi.org/10.1002/ptr.7787 |
| Citation | Abbasifard, M., Jamialahmadi, T.,Reiner,ˇZ., Eid, A. H., & Sahebkar, A. (2023). The effect of nutsconsumption on circulating oxidized low-density lipoproteins:A systematic review and meta-analysis of randomizedcontrolled trials.Phytotherapy Research,1–10.https://doi.org/10.1002/ptr.7787APPENDIX AA.1|Search strategyPubMed, Scopus, Embase, and Web of Science were searched frominception to November 15th, 2021 using the following keywords intitles and abstracts (also in combination with MESH terms): (“mixednuts”OR Nuts OR nut* OR walnut* OR hazelnut* OR pistachio* ORalmond* OR peanut* OR macadamia OR cashew* OR“Brazil nuts”OR“peanut butter”) AND (“Random Allocation"OR“Single-BlindMethod”OR“Double-Blind Method”OR“Cross-Over Studies”OR“Clinical Trials as Topic”OR RCT OR“Intervention Studies”OR inter-vention OR“controlled trial”OR randomized OR randomly OR ran-dom OR placebo OR assignment) AND (“oxidized LDL”OR“oxidizedlow density lipoprotein"OR OxLDL OR“minimally modified oxidized-LDL”OR ox-LDL OR“oxidized Low-Density Lipoprotein"OR MM-LDL OR MMLDL OR“malondialdehyde low density lipoprotein"OR“malondialdehyde-low density lipoprotein"OR“MDA-LDL”OR“MDALDL”).10ABBASIFARDET AL. |
| ISSN | 0951-418X |
| Abstract | This systematic review and meta-analysis evaluated the effect of nuts in decreasing circulating levels of oxidized low-density lipoproteins (ox-LDL). A literature search was performed of major electronic databases (MEDLINE/PubMed, Scopus, and ISI Web of Science) from inception up to November 15th, 2021 to find randomized controlled trials (RCTs) evaluating the effect of different nuts on circulating levels of ox-LDL. The effect size was determined using standardized mean difference (SMD) and corresponding 95% confidence intervals (CI). Evaluation of funnel plot, Begg's rank correlation, and Egger's weighted regression tests were used to assess the presence of publication bias in the meta-analysis. This systematic review and meta-analysis included 15 RCTs involving 997 subjects. Meta-analysis showed that nuts significantly decreased serum levels of ox-LDL. Besides, meta-regression results of the association between confounders such as duration of nuts consumption or delta LDL-cholesterol and levels of ox-LDL, were not significant. The correlation between nuts type and ox-LDL levels was significant in subgroup analyses suggesting the most significant effect of pistachios consumption on reducing the circulating concentrations of ox-LDL. To conclude, nuts consumption decreases the circulating concentrations of ox-LDL which might be beneficial for the prevention and/or progression of ASCVD. |
| Language | en |
| Publisher | Wiley |
| Subject | cardiovascular disease nuts, pistachios oxidized LDL walnuts |
| Type | Article Review |
| ESSN | 1099-1573 |
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