Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer
| Author | Alizadeh, Javad |
| Author | Kavoosi, Mahboubeh |
| Author | Singh, Navjit |
| Author | Lorzadeh, Shahrokh |
| Author | Ravandi, Amir |
| Author | Kidane, Biniam |
| Author | Ahmed, Naseer |
| Author | Mraiche, Fatima |
| Author | Mowat, Michael R. |
| Author | Ghavami, Saeid |
| Available date | 2023-06-21T06:46:23Z |
| Publication Date | 2023-04-07 |
| Publication Name | Cancers |
| Identifier | http://dx.doi.org/10.3390/cancers15082195 |
| Citation | Alizadeh, J., Kavoosi, M., Singh, N., Lorzadeh, S., Ravandi, A., Kidane, B., ... & Ghavami, S. (2023). Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer. |
| ISSN | 2072-6694 |
| Abstract | Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation, is closely associated with metabolism in mammalian cells, acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. In addition, we discuss the impact of these metabolic pathways on autophagy in lung cancer. |
| Sponsor | This work was supported by the CancerCare Manitoba Operating grant (763117252) funded by CancerCare Manitoba Foundation, a Vanier CIHR Ph.D. studentship, and the Max Rady College of Medicine’s BSc (Med) program. |
| Language | en |
| Publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
| Subject | Bcl2 family protein ceramide metabolism glycolysis mitophagy non-small cell lung carcinoma Warburg effect |
| Type | Article |
| Issue Number | 8 |
| Volume Number | 15 |
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