Evaluation of anti-melanoma activities of (1S,2E,4R,6E,8R,11S,12R)-8,12- epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy- 2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol from the Red Sea soft coral Sarcophyton glaucum
المؤلف | Szymanski, Pawel T. |
المؤلف | Ahmed, Safwat A. |
المؤلف | Radwan, Mohamed M. |
المؤلف | Khalifa, Sherief I. |
المؤلف | Fahmy, Hesham |
تاريخ الإتاحة | 2016-05-26T12:20:01Z |
تاريخ النشر | 2014-08 |
اسم المنشور | Natural Product Communications |
المصدر | Scopus |
الاقتباس | Szymanski, P.T., Ahmed, S.A., Radwan, M.M., Khalifa, S.I., Fahmy, H. "Evaluation of anti-melanoma activities of (1S,2E,4R,6E,8R,11S,12R)-8,12- epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy- 2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol from the Red Sea soft coral Sarcophyton glaucum" (2014) Natural Product Communications, 9 (8), pp. 1143-1146. |
الرقم المعياري الدولي للكتاب | 1934-578X |
الملخص | Three natural cembranoids from the Red Sea soft coral Sarcophyton glaucum namely (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol were evaluated for their inhibitory effects on mouse melanoma B16F10 cell growth. Results show that all the cembranoids strongly inhibit viability of melanoma cells particularly during 48-72 hrs treatment and also inhibit de novo DNA synthesis and PARP activity and stimulate fragmentation of DNA. (1S,2E,4R,6E,8R,11S,12R)- 8,12-epoxy-2,6-cembradiene-4,11-diol was not cytotoxic to monkey kidney CV-1 cells at the concentration that produces the anti-melanoma effects which indicates that this compound may be a good candidate for further development. (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol were found to be cytotoxic to healthy cells. |
راعي المشروع | The Translational Cancer Research Center (TCRC) funded by The Research and Commercialization Council, State of South Dakota, USA. |
اللغة | en |
الناشر | Natural Product Communications |
الموضوع | Cembranoids Melanoma Sarcophine Sarcophyton glaucum Skin cancer |
النوع | Article |
الصفحات | 1143-1146 |
رقم العدد | 8 |
رقم المجلد | 9 |
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