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المؤلفSzymanski, Pawel T.
المؤلفAhmed, Safwat A.
المؤلفRadwan, Mohamed M.
المؤلفKhalifa, Sherief I.
المؤلفFahmy, Hesham
تاريخ الإتاحة2016-05-26T12:20:01Z
تاريخ النشر2014-08
اسم المنشورNatural Product Communications
المصدرScopus
الاقتباسSzymanski, P.T., Ahmed, S.A., Radwan, M.M., Khalifa, S.I., Fahmy, H. "Evaluation of anti-melanoma activities of (1S,2E,4R,6E,8R,11S,12R)-8,12- epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy- 2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol from the Red Sea soft coral Sarcophyton glaucum" (2014) Natural Product Communications, 9 (8), pp. 1143-1146.
الرقم المعياري الدولي للكتاب1934-578X
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4574
الملخصThree natural cembranoids from the Red Sea soft coral Sarcophyton glaucum namely (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol were evaluated for their inhibitory effects on mouse melanoma B16F10 cell growth. Results show that all the cembranoids strongly inhibit viability of melanoma cells particularly during 48-72 hrs treatment and also inhibit de novo DNA synthesis and PARP activity and stimulate fragmentation of DNA. (1S,2E,4R,6E,8R,11S,12R)- 8,12-epoxy-2,6-cembradiene-4,11-diol was not cytotoxic to monkey kidney CV-1 cells at the concentration that produces the anti-melanoma effects which indicates that this compound may be a good candidate for further development. (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol were found to be cytotoxic to healthy cells.
راعي المشروعThe Translational Cancer Research Center (TCRC) funded by The Research and Commercialization Council, State of South Dakota, USA.
اللغةen
الناشرNatural Product Communications
الموضوعCembranoids
Melanoma
Sarcophine
Sarcophyton glaucum
Skin cancer
العنوانEvaluation of anti-melanoma activities of (1S,2E,4R,6E,8R,11S,12R)-8,12- epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy- 2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol from the Red Sea soft coral Sarcophyton glaucum
النوعArticle
الصفحات1143-1146
رقم العدد8
رقم المجلد9
dc.accessType Abstract Only


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