Browsing Biomedical Research Center Research by Author "Al-Shafai, Mashael"
Now showing items 1-4 of 4
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Effect of Water-Pipe Smoking on the Normal Development of Zebrafish
Zakaria, Zain Zaki; Aladwi, Shaima Ahmad; Benslimane, Fatiha; Al-Absi, Enas S.; Al-Shafai, Mashael; Yalcin, Huseyin C.; Khalil, Ashraf; Al Moustafa, Ala-Eddin; Al-Asmakh, Maha... more authors ... less authors ( MDPI , 2021 , Article)Background: Among all types of tobacco consumption,Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully ... -
The genetic basis and the diagnostic yield of genetic testing related to nonsyndromic hearing loss in Qatar
Alkhidir, Shaza; El-Akouri, Karen; Al-Dewik, Nader; Khodjet-El-khil, Houssein; Okashah, Sarah; Islam, Nazmul; Ben-Omran, Tawfeg; Al-Shafai, Mashael... more authors ... less authors ( Springer Nature , 2024 , Article)Hearing loss is the most predominant sensory defect occurring in pediatrics, of which, 66% cases are attributed to genetic factors. The prevalence of hereditary hearing loss increases in consanguineous populations, and the ... -
The role of genetic and epigenetic GNAS alterations in the development of early-onset obesity
Alaa, Abbas; Hammad, Ayat S; Al-Shafai, Mashael ( Elsevier , 2023 , Article)BackgroundGNAS (guanine nucleotide-binding protein, alpha stimulating) is an imprinted gene that encodes Gsα, the α subunit of the heterotrimeric stimulatory G protein. This subunit mediates the signalling of a diverse ... -
Understanding the genetics of early onset obesity in a cohort of children from Qatar.
Mohammed, Idris; Haris, Basma; Al-Barazenji, Tara; Vasudeva, Dhanya; Tomei, Sara; Al Azwani, Iman; Dauleh, Hajar; Shehzad, Saira; Chirayath, Shiga; Mohamadsalih, Ghassan; Petrovski, Goran; Khalifa, Amel; Love, Donald R; Al-Shafai, Mashael; Hussain, Khalid... more authors ... less authors ( Oxford University Press , 2023 , Article)Monogenic obesity is a rare form of obesity due to pathogenic variants in genes implicated in the leptin-melanocortin signaling pathway and accounts for around 5% of severe early onset obesity. Mutations in the genes ...