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المؤلفSotgia, Salvatore
المؤلفMangoni, Arduino A.
المؤلفForteschi, Mauro
المؤلفMurphy, Rhys B.
المؤلفElliot, David
المؤلفSotgiu, Elisabetta
المؤلفPintus, Gianfranco
المؤلفCarru, Ciriaco
المؤلفZinellu, Angelo
تاريخ الإتاحة2016-10-12T10:27:20Z
تاريخ النشر2016-09-28
اسم المنشورMolecules
المعرّفhttp://dx.doi.org/10.3390/molecules21101298
الاقتباسSotgia, S.; Mangoni, A.A.; Forteschi, M.; Murphy, R.B.; Elliot, D.; Sotgiu, E.; Pintus, G.; Carru, C.; Zinellu, A. Identification of the Main Intermediate Precursor of l-Ergothioneine Biosynthesis in Human Biological Specimens. Molecules 2016, 21, 1298.
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4876
الملخصA capillary electrophoresis coupled to tandem mass spectrometry (CE–MS/MS) has been used to make a qualitative determination of hercynine—the main precursor of l-ergothioneine biosynthesis—in some key human biological specimens, such as urine, whole blood, plasma, and saliva. From semiquantitative analysis results, the highest concentrations of hercynine were detected in saliva and whole blood, whereas much lower concentrations were measured in urine and plasma. Whole blood was the biological matrix with the highest concentration of l-ergothioneine followed by plasma, saliva, and urine. The antioxidant effects attributed to l-ergothioneine, along with its peculiar antioxidant mechanism, offer a possible explanation for the presence of the hercynine, as well as its concentration, in the considered biological matrices.
راعي المشروع"Fondazione Banco di Sardegna”, Sassari, Italy, and by the “Ministero dell’Università e della Ricerca”, Italy
اللغةen
الناشرMDPI AG
الموضوعaminothione
capillary electrophoresis
mass spectrometry
quaternary ammonium
dismutation
العنوانIdentification of the Main Intermediate Precursor of l-Ergothioneine Biosynthesis in Human Biological Specimens
النوعArticle
رقم العدد10
رقم المجلد21
ESSN1420-3049
dc.accessType Open Access


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