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المؤلفSampath, Chethan
المؤلفRashid, Muhammed Raihan
المؤلفSang, Shengmin
المؤلفAhmedna, Mohamed
تاريخ الإتاحة2017-02-22T11:31:08Z
تاريخ النشر2017-03-01
اسم المنشورBiomedicine & Pharmacotherapy
المعرّفhttp://dx.doi.org/10.1016/j.biopha.2016.12.082
الاقتباسChethan Sampatha, Muhammed Raihan Rashida, Shengmin Sangb, Mohamed Ahmednaa. “Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity”, Volume 87, pp. 73-81
الرقم المعياري الدولي للكتاب07533322
معرّف المصادر الموحدhttp://www.sciencedirect.com/science/article/pii/S0753332216319928
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5300
الملخصAbstract Epigallocatechin 3-gallate (EGCG) from green tea may reduce plasma glucose and alleviate complications of diabetes by attenuating advanced glycation end products (AGEs) formation. We hypothesized that EGCG would mitigate AGEs formation via activating the nuclear factor erythroid-2-related-factor-2 (Nrf2) pathway in a mouse model of high fat diet-induced obesity. Dietary EGCG was tested in C57BL/6 mice that were placed on a high-fat diet with or without ECGC for 17 weeks and compared to a control group placed on low-fat diet for the same period. Weight gain and fasting blood glucose were measured throughout the study duration. Supplementation of high fat diet with dietary EGCG significantly reduced weight gain, plasma glucose, insulin level, liver and kidney weight. EGCG administration also decreased the levels of AGEs in both plasma and liver while inhibiting the receptor for AGE (RAGE) expression of, activating Nrf2 and enhancing GSH/GSSG ratio compared to mice on high fat diet without added EGCG. This study demonstrated that EGCG has the potential to help control hyperglycemia, reduce weight, and alleviate diabetes complications.
راعي المشروعQatar National Research Fund
اللغةen
الناشرElsevier
الموضوعDiabetes
Advance glycation end-products
Epigallocatechin gallate
Nrf2
Dicarbonyl stress
RAGE
العنوانGreen tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity
النوعArticle
الصفحات73-81
رقم المجلد87


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