Browsing Biomedical Research Center by Author "Cenciarelli, Carlo"
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Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation.
Pozzoli, Giacomo; Marei, Hany E; Althani, Asma; Boninsegna, Alma; Casalbore, Patrizia; Marlier, Lionel N J L; Lanzilli, Giulia; Zonfrillo, Manuela; Petrucci, Giovanna; Rocca, Bianca; Navarra, Pierluigi; Sgambato, Alessandro; Cenciarelli, Carlo... more authors ... less authors ( Wiley , 2019 , Article)Several clinical studies indicated that the daily use of aspirin or acetylsalicylic acid reduces the cancer risk via cyclooxygenases (Cox-1 and Cox-2) inhibition. In addition, aspirin-induced Cox-dependent and -independent ... -
Cholinergic and dopaminergic neuronal differentiation of human adipose tissue derived mesenchymal stem cells.
Marei, Hany El Sayed; El-Gamal, Aya; Althani, Asma; Afifi, Nahla; Abd-Elmaksoud, Ahmed; Farag, Amany; Cenciarelli, Carlo; Thomas, Caceci; Anwarul, Hasan... more authors ... less authors ( Wiley , 2018 , Article)Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into various cell types such as cartilage, bone, and fat cells. Recent studies have shown that induction of MSCs in vitro by growth factors including ... -
Common and Rare Genetic Variants Associated With Alzheimer's Disease
Marei, Hany E.; Althani, Asmaa; Suhonen, Jaana; El Zowalaty, Mohamed E.; Albanna, Mohammad A.; Cenciarelli, Carlo; Wang, Tengfei; Caceci, Thomas... more authors ... less authors ( WILEY PERIODICALS, INC. , 2016 , Article)Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis ... -
Differentiation of human olfactory bulb-derived neural stem cells toward oligodendrocyte.
Marei, Hany E; Shouman, Zeinab; Althani, Asma; Afifi, Nahla; A, Abd-Elmaksoud; Lashen, Samah; Hasan, Anwarul; Caceci, Thomas; Rizzi, Roberto; Cenciarelli, Carlo; Casalbore, Patrizia... more authors ... less authors ( Wiley , 2018 , Article)In the central nervous system (CNS), oligodendrocytes are the glial element in charge of myelin formation. Obtaining an overall presence of oligodendrocyte precursor cells/oligodendrocytes (OPCs/OLs) in culture from different ... -
Glioma extracellular vesicles for precision medicine: prognostic and theragnostic application
Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Hasan, Anwarul; Caceci, Thomas; Cifola, Ingrid; Caratelli, Sara; Sconocchia, Giuseppe; D’Agnano, Igea; Cenciarelli, Carlo... more authors ... less authors ( Springer , 2022 , Article Review)EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to ... -
Human Olfactory Bulb Neural Stem Cells Expressing hNGF Restore Cognitive Deficit in Alzheimer's Disease Rat Model
Marei, Hany E.; Farag, Amany; Al-Thani, Asma; Afifi, Nahla; Abd-Elmaksoud, Ahmed; Lashen, Samah; Rezk, Shaymaa; Pallini, Roberto; Casalbore, Patrizia; Cenciarelli, Carlo... more authors ... less authors ( Wiley , 2015 , Article)In this study, we aim to demonstrate the fate of allogenic adult human olfactory bulb neural stem/progenitor cells (OBNSC/NPCs) transplanted into the rat hippocampus treated with ibotenic acid (IBO), a neurotoxicant ... -
Human olfactory bulb neural stem cells mitigate movement disorders in a rat model of Parkinson's disease.
Marei, Hany E S; Lashen, Samah; Farag, Amany; Althani, Asmaa; Afifi, Nahla; A, Abd-Elmaksoud; Rezk, Shaymaa; Pallini, Roberto; Casalbore, Patrizia; Cenciarelli, Carlo... more authors ... less authors ( Wiley , 2015 , Article)Parkinson's disease (PD) is a neurological disorder characterized by the loss of midbrain dopaminergic (DA) neurons. Neural stem cells (NSCs) are multipotent stem cells that are capable of differentiating into different ... -
The Interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets
Cenciarelli, Carlo; E. Marei, Hany; Zonfrillo, Manuela; Casalbore, Patrizia; Felsani, Armando; Trevisi, Gianluca; Althani, Asma; Mangiola, Annunziato... more authors ... less authors ( Impact Journals , 2017 , Article)The invasive and lethal nature of Glioblastoma multiforme (GBM) necessitates the continuous identification of molecular targets and search of efficacious therapies to inhibit GBM growth. The GBM resistance to chemotherapy ... -
Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches
Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Pozzoli, Giacomo; Caceci, Thomas; Angelini, Franco; Cenciarelli, Carlo... more authors ... less authors ( Springer , 2021 , Article Review)We give a summary of SARS-genetic CoV-2’s structure and evolution, as well as current attempts to develop efficient vaccine and treatment methods for SARS-CoV-2 infection, in this article. Most therapeutic strategies are ... -
PDGFRα depletion attenuates glioblastoma stem cells features by modulation of STAT3, RB1 and multiple oncogenic signals.
Cenciarelli, Carlo; Marei, Hany E.; Felsani, Armando; Casalbore, Patrizia; Sica, Gigliola; Puglisi, Maria Ausiliatrice; Cameron, Angus J.M.; Olivi, Alessandro; Mangiola, Annunziato... more authors ... less authors ( Impact Journals , 2016 , Article)Platelet derived growth factor receptors (PDGFRs) play an important role in tumor pathogenesis, and they are frequently overexpressed in glioblastoma (GBM). Earlier we have shown a higher protein expression of PDGFR isoforms ... -
Recent Perspective About the Amyloid Cascade Hypothesis and Stem Cell-Based Therapy in the Treatment of Alzheimer's Disease
Marei, Hany E.; Althani, Asmaa; Suhonen, Jaana; El Zowalaty, Mohamed E.; Albanna, Mohammad A.; Cenciarelli, Carlo; Wang, Tengfei; Caceci, Thomas... more authors ... less authors ( Bentham Science , 2016 , Book chapter)Alzheimer's disease (AD) is a complex neurodegenerative condition that is clinically characterized by impaired cognitive functions. The major morphologically observed lesion of AD encompasses the accumulation of extracellular ... -
Recent perspective on CAR and Fcγ-CR T cell immunotherapy for cancers: Preclinical evidence versus clinical outcomes.
Marei, Hany E; Althani, Asma; Caceci, Thomas; Arriga, Roberto; Sconocchia, Tommaso; Ottaviani, Alessio; Lanzilli, Giulia; Roselli, Mario; Caratelli, Sara; Cenciarelli, Carlo; Sconocchia, Giuseppe... more authors ... less authors ( Elsevier , 2019 , Article)The chimeric antigen receptor Tcell (CAR-T cell) immunotherapy currently represents a hot research trend and it is expected to revolutionize the field of cancer therapy. Promising outcomes have been achieved using CAR-T ...