Browsing by Author "Zughaier, Susu M."
Now showing items 1-20 of 42
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An Adjuvanted Inactivated SARS-CoV-2 Microparticulate Vaccine Delivered Using Microneedles Induces a Robust Immune Response in Vaccinated Mice
Vijayanand, Sharon; Patil, Smital; Menon, Ipshita; Braz Gomes, Keegan; Kale, Akanksha; Bagwe, Priyal; Uddin, Mohammad N.; Zughaier, Susu M.; D’Souza, Martin J.... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)SARS-CoV-2, the causal agent of COVID-19, is a contagious respiratory virus that frequently mutates, giving rise to variant strains and leading to reduced vaccine efficacy against the variants. Frequent vaccination against ... -
Antibacterial activity of Myrtus communis L. and Melaleuca leucadendron var. cajaputi essential oils against antibiotic-resistant bacterial strains
Donadu, Matthew G.; Chowdhury, Shazeda H.; Elgamal, Mahmoud; Usai, Donatella; Zanetti, Stefania; Zughaier, Susu M.... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: Antimicrobial resistance (AMR) is a global threat to public health. There is a dire need for new antibiotics as AMR threatens our last-resort antibiotics efficacy. 1,2 Myrtle plants have been used in folk ... -
Anticorrosion Properties of Robust and UV-Durable Poly(vinylidene fluoride-co-hexafluoropropylene)/Carbon Nanotubes Superhydrophobic Coating
Radwan, A. Bahgat; Ibrahim, Magdy A.; Ismail, Eman H.; El Basiony, Nasser M.; El-Hout, Soliman I.; Zughaier, Susu M.; Hassiba, Maryam; Hassan, Mohammad K.; Okonkwo, Paul C.; Al-Qahtani, Noora; Abdullah, Aboubakr M.... more authors ... less authors ( American Chemical Society (ACS) , 2024 , Article)Aluminum is vulnerable to corrosion, biofouling, and durability reduction as a result of forming unwanted deposits during their interactions with liquids. In this work, a high-corrosion-resistance superhydrophobic coating ... -
ApoM binds endotoxin contributing to neutralization and clearance by High Density Lipoprotein.
Mousa, Hanaa; Thanassoulas, Angelos; Zughaier, Susu M ( Elsevier , 2023 , Article)HDL possesses anti-inflammatory properties, however, the exact mechanism is not fully understood. Endotoxin is a potent inducers of TLR4 signaling, leading to inflammatory mediators' release. It has been estimated that ... -
Assessing the risk of cardiovascular diseases in relation to shisha smoking among adults in Qatar: An analytical cross-sectional study.
Mahmoud, Elhassan; Eliwa, Ahmed; Elsalakawi, Yasmin; Al-Emadi, Alghalya; Mahmood, Fathima; Al-Qahtani, Noof; Al-Mannai, Wafaa; Farooqui, Habib H; Zughaier, Susu M... more authors ... less authors ( EU European Publishing , 2023 , Article)Tobacco smoking is a preventable cause of disease and death worldwide. Shisha has become a popular method of smoking tobacco. In Qatar, the prevalence of smoking in 2019 was 25.2%, of which 20.9% was smoking shisha. Shisha ... -
Assessment of In Vitro Immunostimulatory Activity of an Adjuvanted Whole-Cell Inactivated Neisseria gonorrhoeae Microparticle Vaccine Formulation
Bagwe, Priyal; Bajaj, Lotika; Gala, Rikhav P.; D’souza, Martin J.; Zughaier, Susu M. ( MDPI , 2022 , Article)The emergence of drug-resistant gonorrhea infections worldwide combined with the lack of a vaccine is alarming. We prepared a novel microparticulate (MP) vaccine formulation using whole-cell inactivated Neisseria gonorrhoeae ... -
Assessment of the Role of Serum 25-Hydroxy Vitamin D Level on Coronary Heart Disease Risk With Stratification Among Patients With Type 2 Diabetes Mellitus
Bener, Abdülbari; Al-Hamaq, Abdulla O.A.A.; Zughaier, Susu M.; Öztürk, Mustafa; Ömer, Abdülkadir ( SAGE Publications , 2020 , Article)© The Author(s) 2020. We investigated the role of vitamin D on glycemic regulation and cardiac complications in patients with type 2 diabetes mellitus (T2DM). A total of 1139 patients (49.3% males vs 50.7% females) were ... -
Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study
Omar, Abeer A.; Radwani, Khadija J.; Al Thani, Maryam K.; Abouzeid, Nadin H.; Qabeel, Yousef E.; Al Shamari, Manwa; Chivese, Tawanda; Zughaier, Susu M.... more authors ... less authors ( Taylor and Francis Ltd. , 2023 , Article)Purpose: Low bicarbonate, a hallmark of metabolic acidosis is associated with various diseases. This study investigated associations between bicarbonate levels with prediabetes and subclinical inflammation among healthy ... -
Bi-attention DoubleUNet: A deep learning approach for carotid artery segmentation in transverse view images for non-invasive stenosis diagnosis
Najmath, Ottakath; Akbari, Younes; Al-Maadeed, Somaya Ali; Bouridane, Ahmed; Zughaier, Susu M.; Chowdhury, Muhammad E.H.... more authors ... less authors ( Elsevier , 2024 , Article)The carotid artery is a vital blood vessel that supplies oxygenated blood to the brain. Blockages in this artery can lead to life-threatening illnesses, making accurate diagnosis essential. While ultrasound (US) imaging ... -
Development of an in-house COVID-19 serology ELISA Test
Chowdhury, Shazeda; Taleb, Sara; Elgamal, Mahmoud; Hassan, Nesyia; Nomikos, Michail; Hssain, Ali Ait; Zughaier, Susu M... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2021 , Article)Background: COVID-19 pandemic created an unprecedented demand for reagents and diagnostic tools to confirm COVID-19 cases. Thus, the development of a robust in-house diagnostic test is considered of high importance. Within ... -
Differentiation and classification of bacterial endotoxins based on surface enhanced Raman scattering and advanced machine learning
Yang, Yanjun; Xu, Beibei; Haverstick, James; Ibtehaz, Nabil; Muszyński, Artur; Chen, Xianyan; Chowdhury, Muhammad E.H.; Zughaier, Susu M.; Zhao, Yiping... more authors ... less authors ( Royal Society of Chemistry , 2022 , Article)Bacterial endotoxin, a major component of the Gram-negative bacterial outer membrane leaflet, is a lipopolysaccharide shed from bacteria during their growth and infection and can be utilized as a biomarker for bacterial ... -
Dynamics of Anti-S IgG Antibodies Titers after the Second Dose of COVID-19 Vaccines in the Manual and Craft Worker Population of Qatar
Bansal, Devendra; Atia, Hassan; Al Badr, Mashael; Nour, Mohamed; Abdulmajeed, Jazeel; Hasan, Amal; Al-Hajri, Noora; Ahmed, Lina; Ibrahim, Rumissa; Zamel, Reham; Mohamed, Almuthana; Pattalaparambil, Hamad; Daraan, Faisal; Chaudhry, Adil; Oraby, Sahar; El-Saleh, Sahar; El-Shafie, Sittana S.; Al-Farsi, Affra Faiz; Paul, Jiji; Ismail, Ahmed; Al-Romaihi, Hamad Eid; Al-Thani, Mohammed Hamad; Doi, Suhail A.R.; Zughaier, Susu M.; Cyprian, Farhan; Farag, Elmobashar; Farooqui, Habib Hasan... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)There is limited seroepidemiological evidence on the magnitude and long-term durability of antibody titers of mRNA and non-mRNA vaccines in the Qatari population. This study was conducted to generate evidence on long-term ... -
An Early Warning Tool for Predicting Mortality Risk of COVID-19 Patients Using Machine Learning
Chowdhury, Muhammad E.H.; Rahman, Tawsifur; Khandakar, Amith; Al-Madeed, Somaya; Zughaier, Susu M.; Doi, Suhail A.R.; Hassen, Hanadi; Islam, Mohammad T.... more authors ... less authors ( Springer , 2021 , Article)COVID-19 pandemic has created an extreme pressure on the global healthcare services. Fast, reliable, and early clinical assessment of the severity of the disease can help in allocating and prioritizing resources to reduce ... -
Editorial: Global excellence in children and health
Bener, Abdulbari; Tewfik, Ihab; Zughaier, Susu M.; Day, Andrew S. ( springer link , 2023 , Other)Cooperation and collaboration within and between countries is an increasingly important component of tackling and overcoming the pressing issues impacting upon children's health and wellbeing. This Research Topic (RT) aimed ... -
Editorial: Immune-Modulatory Effects of Vitamin D
Zughaier, Susu M.; Lubberts, Erik; Bener, Abdulbari ( Frontiers Media , 2020 , Other)Vitamin D plays an essential role in bone development. However, recent studies are beginning to uncover its role as a modulator of the immune system (1). Several reports have shown associations between vitamin D deficiency ... -
Editorial: Role of Iron in Bacterial Pathogenesis
Zughaier, Susu M.; Cornelis, Pierre ( Frontiers Media S.A. , 2018 , Article)Iron is the fourth-most abundant element on the earth, and it is needed by most organisms, including bacteria. It exists in two oxidation states, Fe2+ and Fe3+, and is involved in many oxido-reduction reactions (Andrews ... -
Editorial: The Role of Vitamin D in Gut Health and Disease in Children
Day, Andrew S.; Bener, Abdulbari; Tewfik, Ihab; Vajro, Pietro; Zughaier, Susu M. ( Frontiers Media , 2022 , Other)The metabolism of vitamin D relies predominantly upon the synthesis of cholecalciferol (vitamin D3) in the epidermis following exposure to sunlight (specifically ultraviolet B rays) and the subsequent hydroxylation to ... -
Exploring the effect of image enhancement techniques on COVID-19 detection using chest X-ray images
Tawsifur, Rahman; Khandakar, Amith; Qiblawey, Yazan; Tahir, Anas; Kiranyaz, Serkan; Abul Kashem, Saad Bin; Islam, Mohammad Tariqul; Al Maadeed, Somaya; Zughaier, Susu M.; Khan, Muhammad Salman; Chowdhury, Muhammad E.H.... more authors ... less authors ( Elsevier , 2021 , Article)Computer-aided diagnosis for the reliable and fast detection of coronavirus disease (COVID-19) has become a necessity to prevent the spread of the virus during the pandemic to ease the burden on the healthcare system. Chest ... -
High–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines
Rinchai, Darawan; Deola, Sara; Zoppoli, Gabriele; Kabeer, Basirudeen Syed Ahamed; Taleb, Sara; Pavlovski, Igor; Maacha, Selma; Gentilcore, Giusy; Toufiq, Mohammed; Mathew, Lisa; Liu, Li; Vempalli, Fazulur Rehaman; Mubarak, Ghada; Lorenz, Stephan; Sivieri, Irene; Cirmena, Gabriella; Dentone, Chiara; Cuccarolo, Paola; Giacobbe, Daniele Roberto; Baldi, Federico; Garbarino, Alberto; Cigolini, Benedetta; Cremonesi, Paolo; Bedognetti, Michele; Ballestrero, Alberto; Bassetti, Matteo; Hejblum, Boris P.; Augustine, Tracy; Van Panhuys, Nicholas; Thiebaut, Rodolphe; Branco, Ricardo; Chew, Tracey; Shojaei, Maryam; Short, Kirsty; Feng, Carl G.; Zughaier, Susu M.; De Maria, Andrea; Tang, Benjamin; Hssain, Ali Ait; Bedognetti, Davide; Grivel, Jean Charles; Chaussabel, Damien... more authors ... less authors ( American Association for the Advancement of Science , 2022 , Article)Knowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via ... -
Identification of a Histone Deacetylase: Epigenetic Impact on Host Gene Expression.
Zughaier, Susu M; Rouquette-Loughlin, Corinne E; Shafer, William M ( MDPI , 2020 , Article)Epigenetic reprogramming in macrophages is termed trained innate immunity, which regulates immune tolerance and limits tissue damage during infection. is a strict human pathogen that causes the sexually transmitted infection ...