Browsing by Author "Gatalica, Zoran"
Now showing items 1-20 of 33
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Abstract B094: Novel method for patient stratification in breast carcinoma based upon spatial analysis of tumor microenvironment
Ziegler, Colleen; Slemons, Isaiah; DeSilva, Chris; Witkowski, Barbara; Mir, Alain; Anandakrishnan, Sangeetha; Farmer, Andrew; Contreras, Elma; Richardson, David; Vranic, Semir; Gatalica, Zoran; Derkach, Dmitry N.... more authors ... less authors ( American Association for Cancer Research , 2019 , Conference Paper)Breast cancer consists of several intrinsic molecular subtypes, providing the basis for clinical treatment decisions. Lately, it is becoming increasingly recognized that factors other than the intrinsic cancer characteristics, ... -
Acinic cell carcinoma of the breast: A comprehensive review
Azra, Ajkunic; Skenderi, Faruk; Shaker, Nada; Akhtar, Saghir; Lamovec, Janez; Gatalica, Zoran; Vranic, Semir... more authors ... less authors ( Elsevier , 2022 , Article)Acinic cell carcinoma of the breast is a rare special subtype of breast cancer in the category of salivary gland-type tumors. It is morphologically similar to acinic cell carcinomas of salivary glands and pancreas and has ... -
Apocrine Carcinoma
Vranic, Semir; Gatalica, Zoran ( Springer , 2020 , Book chapter)Carcinoma with apocrine differentiation (invasive apocrine carcinoma) is defined by “WHO Classification of Tumours of the Breast” as “any invasive carcinoma in which cells show the cytological features of apocrine ... -
Apocrine Carcinoma
Vranic, Semir; Gatalica, Zoran ( Springer, Cham , 2017 , Book chapter)Carcinoma with apocrine differentiation (invasive apocrine carcinoma) is defined by “WHO Classification of Tumours of the Breast” as “any invasive carcinoma in which cells show the cytological features of apocrine cells” ... -
The assessment of tumor-infiltrating lymphocytes in invasive apocrine carcinoma of the breast in relation to the HER2 status.
Gatalica, Zoran; Kuzmova, Nataliya; Rose, Inga; Ulamec, Monika; Peric Balja, Melita; Skenderi, Faruk; Vranić, Semir... more authors ... less authors ( Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina , 2023 , Article)In the current study, we assessed the prevalence and molecular features of HER2-low phenotype in the apocrine carcinomas of the breast (ApoCa) and its relationship with tumor-infiltrating lymphocytes (TILs). A cohort of ... -
Biomarkers of Targeted Therapy and Immuno-Oncology in Cancers Metastatic to the Breast.
Vranic, Semir; Senarathne, Wijendra; Stafford, Phillip; Poorman, Kelsey; Pockaj, Barbara A; Gatalica, Zoran... more authors ... less authors ( Lippincott, Williams & Wilkins , 2019 , Article)The breast is a rare site for metastases, and their molecular characteristics have not been studied yet. Intrinsic molecular genetics, cancer characteristics, and breast tissue immune responses in diverse metastases to the ... -
Comparison of the biomarkers for targeted therapies in primary extra-mammary and mammary Paget's disease.
Gatalica, Zoran; Vranic, Semir; Krušlin, Božo; Poorman, Kelsey; Stafford, Phillip; Kacerovska, Denisa; Senarathne, Wijendra; Florento, Elena; Contreras, Elma; Leary, Alexandra; Choi, April; In, Gino K... more authors ... less authors ( Wiley Open Access , 2020 , Article)Primary Extra-mammary Paget's disease (EMPD) is a very rare cutaneous adenocarcinoma affecting anogenital or axillary regions. It is characterized by a prolonged course with recurrences and eventually distant metastatic ... -
Composition of the immune microenvironment differs between carcinomas metastatic to the lungs and primary lung carcinomas.
Senarathne, Wijendra; Vranic, Semir; Xiu, Joanne; Rose, Inga; Gates, Peggy; Gatalica, Zoran... more authors ... less authors ( Elsevier , 2018 , Article)Lungs are among the most common sites for development of both primary and metastatic carcinomas. Tumor cells expression (TC) of PD-L1 is an important predictor of the of response to immune check-point inhibition in NSCLC, ... -
Comprehensive analysis of cancers of unknown primary for the biomarkers of response to immune checkpoint blockade therapy
Gatalica, Zoran; Xiu, Joanne; Swensen, Jeff; Vranic, Semir ( Elsevier Ltd , 2018 , Article)Background: Cancer of unknown primary (CUP) accounts for approximately 3% of all malignancies. Avoiding immune destruction is a major cancer characteristic and therapies aimed at immune checkpoint blockade are in use for ... -
Comprehensive genomic profiling of a metastatic small cell lung carcinoma with a complete and long-term response to atezolizumab: A case report
Tomic, Kresimir; Karan Krizanac, Dragana; Skenderi, Faruk; Krpina, Kristina; Carapina Bilic, Andrea; Galic, Kristina; Gatalica, Zoran; Vranic, Semir... more authors ... less authors ( Elsevier , 2023 , Article)Small cell lung cancer (SCLC) is a highly aggressive malignancy with a poor outcome. We present the case of a 57-year-old male patient with extensive-stage (ES-SCLC) treated with chemotherapy and atezolizumab. A complete ... -
Comprehensive molecular profiling of advanced/metastatic olfactory neuroblastomas.
Topcagic, Jasmina; Feldman, Rebecca; Ghazalpour, Anatole; Swensen, Jeffrey; Gatalica, Zoran; Vranic, Semir... more authors ... less authors ( Public Library of Science , 2018 , Article)Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and there are no specific treatment ... -
Glycogen-rich Clear Cell Carcinoma of the Breast: A Comprehensive Review.
Vranic, Semir; Skenderi, Faruk; Beslagic, Vanesa; Gatalica, Zoran ( Lippincott, Williams & Wilkins , 2020 , Article Review)Glycogen-rich clear cell carcinoma (GRCC) is a very rare form of primary breast cancer (<0.1% of all breast cancers). It is characterized by the presence of neoplastic cells with a glycogen-abundant clear cytoplasm (the ... -
HER2-positive apocrine carcinoma of the breast: a population-based analysis of treatment and outcome.
Skenderi, Faruk; Alahmad, Mohamad Alhoda Mohamad; Tahirovic, Emin; Alahmad, Yaman M; Gatalica, Zoran; Vranic, Semir... more authors ... less authors ( Springer , 2022 , Other)Apocrine carcinoma of the breast (APO) expresses HER2 in 30-50% of cases. This study explored the clinicopathological features and outcome of HER2+/APO and matched HER2+/NST cohort. We used the SEER database to explore the ... -
Immunohistochemistry-Enabled Precision Medicine
Gatalica, Zoran; Feldman, Rebecca; Vranic, Semir; Spetzler, David ( Springer, Cham , 2019 , Book chapter)Immunohistochemistry (IHC) can be applied to diagnostic aspects of pathologic examination to provide aid in assignment of lineage and histologic type of cancer. Increasingly, however, IHC is widely used to provide prognostic ... -
Molecular characterization of cancers with NTRK gene fusions
Gatalica, Zoran; Xiu, Joanne; Swensen, Jeffrey; Vranic, Semir ( Springer Nature , 2019 , Article)Targeted inhibitors of neurotropic tyrosine kinases are highly effective in selected patients with gene fusions involving NTRK1, NTRK2, or NTRK3. These fusions are consistently detected in rare cancer types (e.g., secretory ... -
Molecular Profiling of Clear Cell Carcinoma of the Breast Reveals Novel Targetable Biomarkers
Skenderi, Faruk; Palazzo, Juan; Swensen, Jeffrey; Contreras, Elma; Florento, Elena; Gatalica, Zoran; Vranic, Semir... more authors ... less authors ( Springer Nature , 2020 , Conference Paper)Background: Although clear cell morphology may be seen in various subtypes of breast cancer, a pure variant of clear cell carcinoma (usually glycogen-rich) is a very rare primary breast malignancy. It is characterized by ... -
Molecular profiling of the metaplastic spindle cell carcinoma of the breast reveals potentially targetable biomarkers
Semir, Vranic; Stafford, Phillip; Palazzo, Juan; Skenderi, Faruk; Swensen, Jeffrey; Xiu, Joanne; Spetzler, David; Gatalica, Zoran... more authors ... less authors ( Elsevier , 2020 , Article)IntroductionSpindle cell carcinoma is a rare subtype of metaplastic breast cancer (MBC), with triple-negative (TNBC: ER-/PR-/Her2-) phenotype. It is associated with a marked resistance to conventional chemotherapy and has ... -
Molecular Profiling Reveals Limited Targetable Biomarkers in Neuroendocrine Carcinoma of the Cervix.
Cimic, Adela; Vranic, Semir; Arguello, David; Contreras, Elma; Gatalica, Zoran; Swensen, Jeffrey... more authors ... less authors ( Lippincott, Williams & Wilkins , 2020 , Article)Neuroendocrine carcinoma of the cervix (NEC) is a rare and highly aggressive cervical malignancy. Given that no targeted therapy has been approved specifically to NEC, we investigated the presence of novel, potentially ... -
Novel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases.
Skenderi, Faruk; Palazzo, Juan; Swensen, Jeffrey; Feldman, Rebecca; Contreras, Elma; Florento, Elena; Gatalica, Zoran; Vranic, Semir... more authors ... less authors ( Wiley , 2020 , Article)We profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell ... -
Novel therapeutic targets in salivary duct carcinoma uncovered by comprehensive molecular profiling.
Gargano, Stacey M; Senarathne, Wijendra; Feldman, Rebecca; Florento, Elena; Stafford, Phillip; Swensen, Jeffrey; Vranic, Semir; Gatalica, Zoran... more authors ... less authors ( Wiley Open Access , 2019 , Article)Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland malignancy, which often presents at an advanced stage. A proportion of SDC are characterized by HER2 amplification and/or overexpression of androgen receptor ...