Browsing by Author "Smith L."
Now showing items 1-2 of 2
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Interleukin-4 and interleukin-13 evoke scratching behaviour in mice
Campion M.; Smith L.; Gatault S.; Métais C.; Buddenkotte J.; Steinhoff M.... more authors ... less authors ( Blackwell Publishing Ltd , 2019 , Article)Persistent and relapsing itch commonly manifests in inflammatory skin disorders such as atopic dermatitis (AD). AD pathogenesis is driven by interleukin-4 (IL-4) and interleukin-13 (IL-13). Dupilumab, a monoclonal antibody ... -
Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis
Manresa M.C.; Smith L.; Casals-Diaz L.; Fagundes R.R.; Brown E.; Radhakrishnan P.; Murphy S.J.; Crifo B.; Strowitzki M.J.; Halligan D.N.; van den Bogaard E.H.; Niehues H.; Schneider M.; Taylor C.T.; Steinhoff M.... more authors ... less authors ( Blackwell Publishing Ltd , 2019 , Article)Background When an immune cell migrates from the bloodstream to a site of chronic inflammation, it experiences a profound decrease in microenvironmental oxygen levels leading to a state of cellular hypoxia. The hypoxia‐inducible ...