تصفح حسب المؤلف "Gupta, Ishita"
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Circulating miRNAs in HER2-Positive and Triple Negative Breast Cancers: Potential Biomarkers and Therapeutic Targets.
Gupta, Ishita; Rizeq, Balsam; Vranic, Semir; Moustafa, Ala-Eddin Al; Al Farsi, Halema ( MDPI , 2020 , Article)Breast cancer is one of the most prevalent diseases among women worldwide and is highly associated with cancer-related mortality. Of the four major molecular subtypes, HER2-positive and triple-negative breast cancer (TNBC) ... -
Co‑prevalence of human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) in healthy blood donors from diverse nationalities in Qatar
Gupta, Ishita; Nasrallah, Gheyath; Sharma, Anju; Jabeen, Ayesha; Smatti, Maria; Al‑Thawadi, Hamda; Sultan, Ali; Alkhalaf, Moussa; Vranic, Semir; Al Moustafa, Ala‑Eddin... more authors ... less authors ( BMC , 2020 , Article)Background: Infections by both human oncoviruses, human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) are very common in the adult human population and are associated with various malignancies. While HPV is ... -
Dasatinib and PD-L1 inhibitors provoke toxicity and inhibit angiogenesis in the embryo
Maha, Al-Asmakh; Bawadi, Hiba; Hamdan, Munia; Gupta, Ishita; Kheraldine, Hadeel; Jabeen, Ayesha; Rizeq, Balsam; Al Moustafa, Ala-Eddin... more authors ... less authors ( Elsevier , 2021 , Article)Dasatinib is a targeted cancer therapy, while programmed death ligand 1 (PD-L1) inhibitors are a form of immune checkpoint therapy used to treat various types of cancers. Several studies showed the potential efficacy of ... -
Elaeagnus angustifolia Plant Extract Induces Apoptosis via P53 and Signal Transducer and Activator of Transcription 3 Signaling Pathways in Triple-Negative Breast Cancer Cells
Fouzat, Arij; Hussein, Ola Jihad; Gupta, Ishita; Al-Farsi, Halema F.; Khalil, Ashraf; Al Moustafa, Ala Eddin... more authors ... less authors ( Frontiers Media , 2022 , Article)Elaeagnus angustifolia (EA) is used as an alternative medicine in the Middle East to manage numerous human diseases. We recently reported that EA flower extract inhibits cell proliferation and invasion of human oral and ... -
Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells
Jabeen, Ayesha; Sharma, Anju; Gupta, Ishita; Kheraldine, Hadeel; Vranic, Semir; Al Moustafa, Ala-Eddin; Al Farsi, Halema F... more authors ... less authors ( MDPI , 2020 , Article)Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Meanwhile, the outcome of extract on HER2-positive breast cancer remains nascent. Thus, we herein investigated ... -
High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status.
Gupta, Ishita; Al Farsi, Halema; Jabeen, Ayesha; Skenderi, Faruk; Al-Thawadi, Hamda; AlAhmad, Yaman M; Al Moustafa, Ala-Eddin; Vranic, Semir... more authors ... less authors ( MDPI , 2020 , Article)Colorectal cancer (CRC) is a common malignancy with a high mortality rate worldwide. It is a complex, multifactorial disease that is strongly impacted by both hereditary and environmental factors. The role of microbes ... -
High-risk human papillomaviruses and epstein–barr virus in colorectal cancer and their association with clinicopathological status
Gupta, Ishita; Farsi, Halema Al; Jabeen, Ayesha; Skenderi, Faruk; Al-Thawadi, Hamda; Alahmad, Yaman M.; Moustafa, Ala Eddin Al; Vranic, Semir... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Colorectal cancer (CRC) is a common malignancy with a high mortality rate worldwide. It is a complex, multifactorial disease that is strongly impacted by both hereditary and environmental factors. The role of microbes ... -
Incidence of HPVs, EBV and MMTV-like Virus in Breast Cancer in Qatar.
Gupta, Ishita; Al-Sarraf, Reem; Farghaly, Hanan; Vranic, Semir; Sultan, Ali A; Al-Thawadi, Hamda; Al Moustafa, Ala-Eddin; Al-Farsi, Halema F... more authors ... less authors ( Karger Publishers , 2022 , Article)Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these ... -
Mesoporous silica coated carbon nanofibers reduce embryotoxicity via ERK and JNK pathways
Abdo, Ghada G.; Gupta, Ishita; Kheraldine, Hadeel; Rizeq, Balsam; Zagho, Moustafa M.; Khalil, Ashraf; Elzatahry, Ahmed; Al Moustafa, Ala-Eddin... more authors ... less authors ( Elsevier Ltd , 2021 , Article)Carbon nanofibers (CNFs) have been implicated in biomedical applications, yet, they are still considered as a potential hazard. Conversely, mesoporous silica is a biocompatible compound that has been used in various ... -
Novel nitrogen-based chalcone analogs provoke substantial apoptosis in HER2-positive human breast cancer cells via JNK and ERK1/ERK2 signaling pathways
Rizeq, Balsam; Gupta, Ishita; Kheraldine, Hadeel; Elkhalifa, Dana; Al-Farsi, Halema F.; Moustafa, Ala-Eddin A.; Khalil, Ashraf... more authors ... less authors ( MDPI , 2021 , Article)Natural chalcones possess antitumor properties and play a role as inducers of apoptosis, antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone-based compounds, which were generated in our ... -
Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor.
Padmanabhan, Regina; Kheraldine, Hadeel; Gupta, Ishita; Meskin, Nader; Hamad, Anas; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2022 , Article)Immune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers. However, patients with HER2+ ... -
Role of E2F transcription factor in oral cancer: Recent insight and advancements
Amal, Kassab; Gupta, Ishita; Moustafa, Ala-Eddin Al ( Elsevier , 2023 , Article)The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating the expression of several genes related to ... -
SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression
Alateyah, Nouralhuda; Gupta, Ishita; Rusyniak, Radoslaw Stefan; Ouhtit, Allal ( MDPI , 2022 , Article Review)CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s ... -
Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways.
Kheraldine, Hadeel; Gupta, Ishita; Cyprian, Farhan Sachal; Vranic, Semir; Al-Farsi, Halema F; Merhi, Maysaloun; Dermime, Said; Al Moustafa, Ala-Eddin... more authors ... less authors ( Springer Nature , 2024 , Article)Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, including breast ... -
The power of phytochemicals combination in cancer chemoprevention
Rizeq, Balsam; Gupta, Ishita; Ilesanmi, Josephine; AlSafran, Mohammed; Rahman, MD Mizanur; Ouhtit, Allal... more authors ... less authors ( Ivyspring International Publisher , 2020 , Article Review)Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have ...