Browsing by Author "Pedersen, Shona"
Now showing items 1-15 of 15
-
Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics
Jonas Ellegaard, Nielsen; Maltesen, Raluca Georgiana; Havelund, Jesper F.; Færgeman, Nils J.; Gotfredsen, Charlotte Held; Vestergård, Karsten; Kristensen, Søren Risom; Pedersen, Shona... more authors ... less authors ( Elsevier , 2021 , Article)BackgroundAlzheimer's Disease (AD) is a complex and multifactorial disease and novel approaches are needed to illuminate the underlying pathology. Metabolites comprise the end-product of genes, transcripts, and protein ... -
Circulating microvesicles and exosomes in small cell lung cancer by quantitative proteomics
Pedersen, Shona; Jensen, Katrine Papendick; Honoré, Bent; Kristensen, Søren Risom; Pedersen, Camilla Holm; Szejniuk, Weronika Maria; Maltesen, Raluca Georgiana; Falkmer, Ursula... more authors ... less authors ( BMC , 2022 , Article)Background: Early detection of small cell lung cancer (SCLC) crucially demands highly reliable markers. Growing evidence suggests that extracellular vesicles carry tumor cell-specific cargo suitable as protein markers in ... -
Deep Learning-Based Conjunctival Melanoma Detection Using Ocular Surface Images
Podder, Kanchon Kanti; Alam, Mohammad Kaosar; Siam, Zakaria Shams; Islam, Khandaker Reajul; Dutta, Proma; Mushtak, Adam; Khandakar, Amith; Pedersen, Shona; Chowdhury, Muhammad E.H.... more authors ... less authors ( springer link , 2023 , Article)The human eye could be affected with conjunctival melanoma, which indicates a fatal malignant growth of the eye. Being a very rare disease, there exists a lack of related data in the literature. Also, very few studies ... -
Exploring the Role of microRNAs in Glioma Progression, Prognosis, and Therapeutic Strategies
Tluli, Omar; Al-Maadhadi, Mazyona; Al-Khulaifi, Aisha Abdulla; Akomolafe, Aishat F.; Al-Kuwari, Shaikha Y.; Al-Khayarin, Roudha; Maccalli, Cristina; Pedersen, Shona... more authors ... less authors ( MDPI , 2023 , Article)Gliomas, which arise from glial cells in the brain, remain a significant challenge due to their location and resistance to traditional treatments. Despite research efforts and advancements in healthcare, the incidence of ... -
Fetal ECG extraction from maternal ECG using deeply supervised LinkNet++ model
Arafat, Rahman; Mahmud, Sakib; Chowdhury, Muhammad E.H.; Yalcin, Huseyin Cagatay; Khandakar, Amith; Mutlu, Onur; Mahbub, Zaid Bin; Kamal, Reema Yousef; Pedersen, Shona... more authors ... less authors ( Elsevier , 2023 , Article)Fetal heart monitoring and early disease detection using non-invasive fetal electrocardiograms (fECG) can help substantially to reduce infant death through improved diagnosis of Coronary Heart Disease (CHD) in the fetus. ... -
Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review
Gupta, Ishita; Pedersen, Shona; Vranic, Semir; Al Moustafa, Ala Eddin ( MDPI , 2022 , Article Review)Advancement in the development of molecular sequencing platforms has identified infectious bacteria or viruses that trigger the dysregulation of a set of genes inducing the epithelial– mesenchymal transition (EMT) event. ... -
Mechanisms underlying the effects of caloric restriction on hypertension
Ahmad A., Al Attar; Fahed, Gracia I.; Hoballah, Malak M.; Pedersen, Shona; El-Yazbi, Ahmed F.; Nasser, Suzanne A.; Bitto, Alessandra; Orekhov, Alexander N.; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article)Hypertension is a major risk factor for cardiovascular disease (CVD) as well as a major contributor to all-cause mortality and disability worldwide. The pathophysiology of hypertension is highly attributed to a dysfunctional ... -
NDDNet: a deep learning model for predicting neurodegenerative diseases from gait pattern
Faisal, Md Ahasan Atick; Chowdhury, Muhammad E.H.; Mahbub, Zaid Bin; Pedersen, Shona; Ahmed, Mosabber Uddin; Khandakar, Amith; Alhatou, Mohammed; Nabil, Mohammad; Ara, Iffat; Bhuiyan, Enamul Haque; Mahmud, Sakib; AbdulMoniem, Mohammed... more authors ... less authors ( Springer Nature , 2023 , Article)Neurodegenerative diseases damage neuromuscular tissues and deteriorate motor neurons which affects the motor capacity of the patient. Particularly the walking gait is greatly influenced by the deterioration process. Early ... -
A novel deep learning technique for morphology preserved fetal ECG extraction from mother ECG using 1D-CycleGAN
Promit, Basak; Nazmus Sakib, A.H.M; Chowdhury, Muhammad E.H.; Al-Emadi, Nasser; Cagatay Yalcin, Huseyin; Pedersen, Shona; Mahmud, Sakib; Kiranyaz, Serkan; Al-Maadeed, Somaya... more authors ... less authors ( Elsevier , 2024 , Article)The non-invasive fetal electrocardiogram (fECG) enables easy detection of developing heart abnormalities, leading to a significant reduction in infant mortality rate and post-natal complications. Due to the overlapping of ... -
Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review
Elshoeibi, Amgad Mohamed; Elsayed, Basel; Kaleem, Muhammad Zain; Elhadary, Mohamed Ragab; Abu-Haweeleh, Mohannad Natheef; Haithm, Yunes; Krzyslak, Hubert; Vranic, Semir; Pedersen, Shona... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)The accurate diagnosis of small-cell lung cancer (SCLC) is crucial, as treatment strategies differ from those of other lung cancers. This systematic review aims to identify proteins differentially expressed in SCLC compared ... -
The Role of Apolipoproteins in the Commonest Cancers: A Review
Darwish, Nour M.; Al-Hail, Mooza Kh; Mohamed, Youssef; Al Saady, Rafif; Mohsen, Sara; Zar, Amna; Al-Mansoori, Layla; Pedersen, Shona... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Apolipoproteins (APOs) are vital structural components of plasma lipoproteins that are involved in lipid metabolism and transport. Recent studies have reported an association between apolipoprotein dysregulation and the ... -
Role of HMGB1 and its associated signaling pathways in human malignancies
Sourour, Idoudi; Bedhiafi, Takwa; Pedersen, Shona; Elahtem, Mohamed; Alremawi, Izzaldin; Akhtar, Sabah; Dermime, Said; Merhi, Maysaloun; Uddin, Shahab... more authors ... less authors ( Elsevier , 2023 , Article)The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 ... -
Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition: a validation study
Nielsen, Jonas Ellegaard; Andreassen, Trygve; Gotfredsen, Charlotte Held; Olsen, Dorte Aalund; Vestergaard, Karsten; Madsen, Jonna Skov; Kristensen, Søren Risom; Pedersen, Shona... more authors ... less authors ( Springer , 2024 , Article)Introduction: Alzheimer’s Disease (AD) is complex and novel approaches are urgently needed to aid in diagnosis. Blood is frequently used as a source for biomarkers; however, its complexity prevents proper detection. The ... -
Shotgun-based proteomics of extracellular vesicles in Alzheimer’s disease reveals biomarkers involved in immunological and coagulation pathways
Nielsen, Jonas Ellegaard; Honoré, Bent; Vestergård, Karsten; Maltesen, Raluca Georgiana; Christiansen, Gunna; Bøge, Anna Uhd; Kristensen, Søren Risom; Pedersen, Shona... more authors ... less authors ( Nature Research , 2021 , Article)Alzheimer’s disease (AD) is the most common form of dementia and without readily available clinical biomarkers. Blood-derived proteins are routinely used for diagnostics; however, comprehensive plasma profiling is challenging ... -
Thrombin generation measured on ST Genesia, a new platform in the coagulation routine lab: Assessment of analytical and between-subject variation
Kristensen, Søren Risom; Nybo, Jette; Pedersen, Shona ( Wiley Open Access , 2022 , Article)Background: The thrombin generation (TG) assay, which measures global coagulation, has mainly been used as a research tool to investigate thrombotic and bleeding disorders. Recently, Diagnostica Stago launched the ST ...